Analytical Data
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基因名
DNAJB13
- Application
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别名
1700014P03Rik; DJB13_HUMAN; DnaJ (Hsp40) homolog subfamily B member 13; DnaJ (Hsp40) related subfamily B member 13; DnaJ homolog subfamily B member 13; DnaJ like protein; DNAJB13; FLJ46748; Radial spoke 16 homolog A; RSPH16A; testis and spermatogenesis cell related protein 6; Testis and spermatogenesis cell-related protein 6; testis spermatocyte apoptosis related gene 6 protein; Testis spermatocyte apoptosis-related gene 6 protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P59910
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表达区间
1-316aa
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氨基酸序列
MGQDYYSVLG ITRNSEDAQI KQAYRRLALK HHPLKSNEPS SAEIFRQIAE AYDVLSDPMK RGIYDKFGEE GLKGGIPLEF GSQTPWTTGY VFHGKPEKVF HEFFGGNNPF SEFFDAEGSE VDLNFGGLQG RGVKKQDPQV ERDLYLSLED LFFGCTKKIK ISRRVLNEDG YSSTIKDKIL TIDVKPGWRQ GTRITFEKEG DQGPNIIPAD IIFIVKEKLH PRFRRENDNL FFVNPIPLGK ALTCCTVEVR TLDDRLLNIP INDIIHPKYF KKVPGEGMPL PEDPTKKGDL FIFFDIQFPT RLTPQKKQML RQALLT
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分子量
36.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DNAJB13, a member of the DnaJ/Hsp40 protein family, is a co-chaperone that plays a crucial role in protein folding and the management of cellular stress. Its involvement in the heat shock response highlights its significance in cellular homeostasis and the maintenance of proper proteostasis. Recent studies have linked DNAJB13 to various diseases, including neurodegenerative disorders such as Alzheimer’s and Parkinson’s, where misfolded proteins accumulate and contribute to pathology. The overexpression or dysfunction of DNAJB13 has been shown to modulate the aggregation of these proteins, thereby influencing disease progression. Additionally, DNAJB13 has been implicated in cancer biology, where it affects tumor cell survival and response to therapy by regulating the heat shock response. Given its pivotal role in these processes, researchers have increasingly focused on the biochemical and structural characterization of DNAJB13 as a potential therapeutic target. Understanding the mechanisms by which DNAJB13 interacts with client proteins and other molecular chaperones is essential for developing strategies to enhance its protective functions or inhibit its activity in pathological contexts. The recombinant production of DNAJB13 has facilitated in-depth studies of its functional properties, paving the way for novel approaches in treating diseases linked to protein misfolding and aggregation. Overall, the research surrounding DNAJB13 has significant implications not only for basic biology and our understanding of protein dynamics but also for clinical applications in treating various disorders associated with protein misfolding.
