Analytical Data
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Gene name
SRMS
- Application
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Alternative Names
C20orf148; dJ697K14.1; EC 2.7.1.112; Src related kinase lacking C terminal regulatory tyrosine and N terminal myristylation sites; SRM; SRMS; SRMS_HUMAN; Tyrosine protein kinase Srms; Tyrosine-protein kinase Srms
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H3Y6
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Expression Region
1-488aa
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AA Sequence
MEPFLRRRLA FLSFFWDKIW PAGGEPDHGT PGSLDPNTDP VPTLPAEPCS PFPQLFLALY DFTARCGGEL SVRRGDRLCA LEEGGGYIFA RRLSGQPSAG LVPITHVAKA SPETLSDQPW YFSGVSRTQA QQLLLSPPNE PGAFLIRPSE SSLGGYSLSV RAQAKVCHYR VSMAADGSLY LQKGRLFPGL EELLTYYKAN WKLIQNPLLQ PCMPQKAPRQ DVWERPHSEF ALGRKLGEGY FGEVWEGLWL GSLPVAIKVI KSANMKLTDL AKEIQTLKGL RHERLIRLHA VCSGGEPVYI VTELMRKGNL QAFLGTPEGR ALRLPPLLGF ACQVAEGMSY LEEQRVVHRD LAARNVLVDD GLACKVADFG LARLLKDDIY SPSSSSKIPV KWTAPEAANY RVFSQKSDVW SFGVLLHEVF TYGQCPYEGM TNHETLQQIM RGYRLPRPAA CPAEVYVLML ECWRSSPEER PSFATLREKL HAIHRCHP
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Molecular Weight
54.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The study of SRMS (Src-related kinase in mitosis) recombinant protein has garnered significant interest due to its crucial role in cell cycle regulation and mitotic processes. SRMS, a member of the Src family of non-receptor tyrosine kinases, plays a key part in various cellular functions, including cell proliferation, signaling, and migration. Research has indicated that alterations in SRMS expression and activity are implicated in several types of cancer, making it a potential target for therapeutic intervention. Recombinant protein technology allows for the production of SRMS in a controlled environment, facilitating detailed studies on its structure, function, and interactions with other cellular components. Understanding SRMS's specific mechanisms in mitosis can provide valuable insights into tumorigenesis and cell division dysregulation, highlighting its importance not just as a biological marker but also as a promising candidate for drug development. As researchers continue to explore SRMS's pathways and its implications in cancer biology, the potential for novel therapeutic strategies to combat malignancies grows significantly, positioning SRMS at the forefront of molecular oncology research.
