Analytical Data
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Gene name
TCF7L2
- Application
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Alternative Names
TCF7L2；CTNNB；Catenin beta-1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NQB0
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Expression Region
1-456aa
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AA Sequence
MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSSDSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGSLSPTARTLHFQSGSTHYSAYKTIEHQIAVQYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLNPCLSLPPIT
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Molecular Weight
54.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TCF7L2, or T-cell factor 7-like 2, is a crucial transcription factor that plays a significant role in the Wnt signaling pathway, which is vital for various cellular processes including proliferation, differentiation, and stem cell maintenance. Research has highlighted TCF7L2's involvement in numerous physiological and pathological conditions, particularly its strong association with type 2 diabetes mellitus. This relationship has spurred interest in studying TCF7L2 as it may influence insulin sensitivity and pancreatic function. Recombinant protein studies have been initiated to better understand TCF7L2's molecular mechanisms and to explore its potential as a therapeutic target. By utilizing recombinant DNA technology, researchers can produce TCF7L2 in a controlled laboratory setting, allowing for the investigation of its structural properties, binding affinities with other proteins, and its role in gene regulation. The study of TCF7L2 recombinant proteins not only aids in elucidating the pathways involved but also opens avenues for the development of innovative treatments for metabolic disorders and other diseases linked to Wnt signaling dysregulation. As such, TCF7L2 continues to be a focus of research, contributing to our understanding of complex biological systems and offering hope for future therapeutic advancements.
