Analytical Data
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Gene name
NOTCH2NL
- Application
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Alternative Names
NOTCH2NL；N2N；NOTCH2NL；Notch homolog 2 N-terminal-like Protein A
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q7Z3S9
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Expression Region
1-236aa
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AA Sequence
MCVTYHNGTG YCKCPEGFLG EYCQHRDPCE KNRCQNGGTC VAQAMLGKAT CRCASGFTGE DCQYSTSHPC FVSRPCLNGG TCHMLSRDTY ECTCQVGFTG KECQWTDACL SHPCANGSTC TTVANQFSCK CLTGFTGQKC ETDVNECDIP GHCQHGGTCL NLPGSYQCQC LQGFTGQYCD SLYVPCAPSP CVNGGTCRQT GDFTFECNCL PETVRRGTEL WERDREVWNG KEHDEN
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NOTCH2NL is a recently identified protein implicated in neurodevelopment, particularly in the evolution of the human brain. It is a member of the Notch gene family and has been shown to play a critical role in the regulation of neural progenitor cell proliferation and differentiation. NOTCH2NL exhibits distinct structural features that differentiate it from other Notch ligands, suggesting a unique role in signaling pathways. Studies indicate that variations in NOTCH2NL expression levels may influence cognitive abilities and may be linked to neurodevelopmental disorders. Recent research has also highlighted its potential involvement in human brain size expansion, diverging from that of non-human primates. Understanding the molecular mechanisms of NOTCH2NL's action is crucial for comprehending its function in brain development and its contribution to the evolutionary advantages observed in humans. Thus, it is of great interest to characterize NOTCH2NL recombinant proteins for functional assays, which will shed light on their biological roles and potential therapeutic applications in neurological conditions. High-quality recombinant NOTCH2NL proteins can be utilized for structural studies, binding assays, and screening for modulators that may target this pathway, ultimately aiding in the development of new strategies for treating related disorders.
