Analytical Data
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Gene name
PES1
- Application
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Alternative Names
PES1；Pescadillo homolog
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O00541
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Expression Region
1-588aa
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AA Sequence
MGGLEKKKYERGSATNYITRNKARKKLQLSLADFRRLCILKGIYPHEPKHKKKVNKGSTAARTFYLIKDIRFLLHEPIVNKFREYKVFVRKLRKAYGKSEWNTVERLKDNKPNYKLDHIIKERYPTFIDALRDLDDALSMCFLFSTFPRTGKCHVQTIQLCRRLTVEFMHYIIAARALRKVFLSIKGIYYQAEVLGQPIVWITPYAFSHDHPTDVDYRVMATFTEFYTTLLGFVNFRLYQLLNLHYPPKLEGQAQAEAKAGEGTYALDSESCMEKLAALSASLARVVVPATEEEAEVDEFPTDGEMSAQEEDRRKELEAQEKHKKLFEGLKFFLNREVPREALAFIIRSFGGEVSWDKSLCIGATYDVTDSRITHQIVDRPGQQTSVIGRCYVQPQWVFDSVNARLLLPVAEYFSGVQLPPHLSPFVTEKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKREKYLYQKIMFGKRRKIREANKLAEKRKAHDEAVRSEKKAKKARPE
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Molecular Weight
75.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PES1 (Pescadillo homolog 1) is a nucleolar protein that plays a crucial role in ribosome biogenesis and cellular proliferation. Its overexpression has been linked to various cancers, which has prompted extensive research into its functions and potential as a therapeutic target. PES1 is known to interact with several key proteins involved in the processing and assembly of ribosomal RNA, thereby influencing the production of ribosomes and protein synthesis. Studies have shown that PES1 can regulate the cell cycle and apoptosis, highlighting its importance in maintaining cellular homeostasis. The dysregulation of PES1 expression has been found in numerous malignancies, including breast cancer and leukemia, suggesting that it may serve as a biomarker for cancer diagnosis and prognosis. Furthermore, the investigation of PES1 as a target for cancer therapy has gained traction, with researchers exploring inhibitory strategies to diminish its function in tumor cells. Understanding the mechanistic roles of PES1 in ribosome assembly and its implications in cancer pathology may lead to innovative approaches in cancer treatment. This research on PES1 not only provides insights into fundamental cellular mechanisms but also holds promise for its application in clinical settings, potentially offering new avenues for the development of cancer therapeutics. As a result, PES1 stands out as a significant focus of interest in molecular biology and oncology research, warranting further exploration to unravel its complex roles in cellular dynamics and disease.
