Analytical Data
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Gene name
COPRS
- Application
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Alternative Names
COPRS；C17orf79；COPR5；Coordinator of PRMT5 and differentiation stimulator
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NQ92
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Expression Region
1-184aa
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AA Sequence
MDLQAAGAQA QGAAEPSRGP PLPSARGAPP SPEAGFATAD HSSQERETEK AMDRLARGTQ SIPNDSPARG EGTHSEEEGF AMDEEDSDGE LNTWELSEGT NCPPKEQPGD LFNEDWDSEL KADQGNPYDA DDIQESISQE LKPWVCCAPQ GDMIYDPSWH HPPPLIPYYS KMVFETGQFD DAED
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
COPRS (C-terminal binding protein-associated protein) is an important repressor of gene expression that plays a crucial role in various cellular processes, including differentiation, apoptosis, and proliferation. It is known to interact with C-terminal-binding protein (CtBP), a well-characterized transcriptional co-repressor, thus forming a part of a complex regulatory network that modulates gene expression in response to developmental and environmental cues. Studies have shown that COPRS is involved in fundamental biological pathways, and its dysregulation has been linked to various diseases, particularly cancers. In recent years, researchers have focused on elucidating the molecular mechanisms underlying COPRS function, as well as its potential roles in epigenetic regulation and chromatin remodeling. Furthermore, the impact of COPRS on the tumor microenvironment and its interactions with signaling pathways such as Wnt and Notch have garnered significant attention. Investigating COPRS's structure and function could provide valuable insights into its potential as a therapeutic target and contribute to the development of novel strategies for cancer treatment. The ongoing research in this field highlights the necessity of understanding COPRS in the broader context of cellular homeostasis and its implications in human health and disease. Overall, COPRS serves as a promising focal point for advancing our understanding of transcriptional regulation and its impact on cell behavior.
