Analytical Data
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基因名
RORg
- Application
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别名
RORg；NR1F3；RORG；RZRG；Nuclear receptor ROR-gamma
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P51449
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表达区间
1-518aa
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氨基酸序列
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEG CKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDA VKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYT LGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASC HLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDS YGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQI VLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSI FDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAF HHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPP LYKELFSTETESPVGLSK
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RORg (Retinoic Acid Receptor-related Orphan Receptor gamma) is an essential member of the nuclear receptor superfamily that plays a critical role in immune regulation and the development of various tissues, particularly lymphoid organs. Researchers have increasingly focused on RORg due to its pivotal involvement in the differentiation and function of Th17 cells, a subset of T helper cells associated with autoimmune diseases and inflammatory conditions. The identification and characterization of RORg's role in regulating gene expression in response to specific ligands and its interaction with other signaling pathways underscore its potential as a therapeutic target. Additionally, RORg's involvement in circadian rhythm regulation and metabolic processes highlights its broader physiological significance. Recombinant RORg proteins are valuable tools for investigating the receptor's molecular mechanisms and developing RORg-modulating drugs. Understanding RORg's structure-function relationship through recombinant expression and purification techniques can pave the way for therapeutic interventions in diseases where RORg is implicated, such as psoriasis, rheumatoid arthritis, and even cancer. As research on RORg continues to evolve, its therapeutic potential and implications for drug design are becoming increasingly apparent, making it a significant focus within immunology and pharmacology.
