Analytical Data
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Gene name
RIOK1
- Application
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Alternative Names
RIOK1；RIO1；Serine/threonine-Protein kinase RIO1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BRS2
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Expression Region
1-568aa
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AA Sequence
MDYRRLLMSR VVPGQFDDAD SSDSENRDLK TVKEKDDILF EDLQDNVNEN GEGEIEDEEE EGYDDDDDDW DWDEGVGKLA KGYVWNGGSN PQANRQTSDS SSAKMSTPAD KVLRKFENKI NLDKLNVTDS VINKVTEKSR QKEADMYRIK DKADRATVEQ VLDPRTRMIL FKMLTRGIIT EINGCISTGK EANVYHASTA NGESRAIKIY KTSILVFKDR DKYVSGEFRF RHGYCKGNPR KMVKTWAEKE MRNLIRLNTA EIPCPEPIML RSHVLVMSFI GKDDMPAPLL KNVQLSESKA RELYLQVIQY MRRMYQDARL VHADLSEFNM LYHGGGVYII DVSQSVEHDH PHALEFLRKD CANVNDFFMR HSVAVMTVRE LFEFVTDPSI THENMDAYLS KAMEIASQRT KEERSSQDHV DEEVFKRAYI PRTLNEVKNY ERDMDIIMKL KEEDMAMNAQ QDNILYQTVT GLKKDLSGVQ KVPALLENQV EERTCSDSED IGSSECSDTD SEEQGDHARP KKHTTDPDID KKERKKMVKE AQREKRKNKI PKHVKKRKEK TAKTKKGK
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
RIOK1 (RIO kinase 1) is a member of the RIO kinase family, which is implicated in various cellular processes, including ribosome biogenesis, translational control, and response to cellular stress. It has been shown to play a crucial role in the regulation of cell proliferation and differentiation. RIOK1 is characterized by its kinase activity, allowing it to phosphorylate target proteins involved in these processes. Recent studies have identified RIOK1 as a potential player in cancer biology, with alterations in its expression linked to tumor progression and metastasis. Furthermore, RIOK1 has been associated with several signaling pathways, indicating its importance in maintaining cellular homeostasis. The recombinant expression of RIOK1 is essential for understanding its structure-function relationship and the molecular mechanisms underlying its activity. This research not only aims to elucidate the biological functions of RIOK1 but also explores its potential as a therapeutic target in diseases where its dysregulation is observed. By generating RIOK1 recombinant protein, researchers can perform detailed biochemical assays, structural studies, and functional analyses, providing deeper insights into its roles in health and disease. Understanding RIOK1's mechanisms can pave the way for novel interventions in cancer and other disorders related to its dysregulation.
