Analytical Data
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Gene name
GNg8
- Application
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Alternative Names
GNg8；GNG8；GNG9；GNGT8；Guanine nucleotide-binding Protein G(I)/G(S)/G(O) subunit gamma-T2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UK08
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Expression Region
1-67aa
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AA Sequence
MSNNMAKIAE ARKTVEQLKL EVNIDRMKVS QAAAELLAFC ETHAKDDPLV TPVPAAENPF RDKRLFC
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The GNg8 protein has garnered significant attention in the field of molecular biology and biochemistry due to its pivotal role in intracellular signaling pathways. As a guanine nucleotide-binding protein, GNg8 is involved in various physiological processes, including cell growth, differentiation, and apoptosis. Its function is intricately linked to the regulation of cyclic AMP and other secondary messengers, making it a critical component in mediating cellular responses to external stimuli. The study of GNg8 has expanded in recent years, driven by the need to understand its implications in various diseases, including cancer and metabolic disorders. Researchers have sought to investigate the structural and functional properties of GNg8, leading to the development of recombinant versions of the protein for experimental purposes. This recombinant GNg8 can be used in high-throughput screens to identify potential drug candidates, elucidate signaling mechanisms, and explore its interactions with other protein partners. Furthermore, the expression and purification of GNg8 in heterologous systems have opened new avenues for functional assays, paving the way for innovative therapeutic strategies that target GNg8-related pathways. Understanding the intricacies of GNg8’s role in cellular signaling not only enhances our knowledge of fundamental biological processes but also holds promise for developing targeted interventions in diseases associated with GNg8 dysregulation. Overall, ongoing research into the GNg8 recombinant protein is crucial for uncovering its potential as a therapeutic target and for expanding the horizons of molecular medicine.
