Analytical Data
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基因名
DDX49
- Application
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别名
Probable ATP-dependent RNA helicase DDX49. EC:3.6.4.13. DEAD box protein 49
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y6V7
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表达区间
1-483aa
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氨基酸序列
MAGFAELGLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPYGIFCLVLTPTRELAYQIAEQFRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLRSSNTFSIKKIRFLVMDEADRLLEQGCTDFTVDLEAILAAVPARRQTLLFSATLTDTLRELQGLATNQPFFWEAQAPVSTVEQLDQRYLLVPEKVKDAYLVHLIQRFQDEHEDWSIIIFTNTCKTCQILCMMLRKFSFPTVALHSMMKQKERFAALAKFKSSIYRILIATDVASRGLDIPTVQVVINHNTPGLPKIYIHRVGRTARAGRQGQAITLVTQYDIHLVHAIEEQIKKKLEEFSVEEAEVLQILTQVNVVRRECEIKLEAAHFDEKKEINKRKQLILEGKDPDLEAKRKAELAKIKQKNRRFKEKVEETLKRQKAGRAGHKGRPPRTPSGSHSGPVPSQGLV
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分子量
80.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DDX49, a member of the DEAD-box family of RNA helicases, plays a crucial role in various cellular processes, including RNA metabolism, translation regulation, and stress response. The DEAD-box proteins, characterized by their conserved motifs, are known to unwind RNA structures, facilitating the recruitment of ribonucleoprotein complexes and promoting RNA processing events such as splicing and translation initiation. Research into DDX49 has gained momentum due to its potential implications in cellular differentiation and development, as well as its involvement in various diseases, including cancer. Aberrant expression or dysfunction of DDX49 has been linked to disrupted cellular homeostasis, impacting RNA regulation pathways. Moreover, understanding the structural and functional aspects of DDX49 can provide insights into its mechanisms of action in RNA processing and metabolic regulation. Furthermore, the development of DDX49 recombinant proteins may offer valuable tools for investigating its biological functions and interactions, paving the way for therapeutic applications targeting DDX49-related pathways. As such, ongoing research aims to elucidate the precise roles of DDX49 in cellular contexts, ultimately contributing to our understanding of its broader significance in health and disease.
