Analytical Data
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基因名
DDX39
- Application
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别名
DDX39A; DDX39; ATP-dependent RNA helicase DDX39A; EC 3.6.4.13; DEAD box protein 39; Nuclear RNA helicase URH49
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O00148
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表达区间
1-427aa
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氨基酸序列
MAEQDVENDLLDYDEEEEPQAPQESTPAPPKKDIKGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQIEPVNGQVTVLVMCHTRELAFQISKEYERFSKYMPSVKVSVFFGGLSIKKDEEVLKKNCPHVVVGTPGRILALVRNRSFSLKNVKHFVLDECDKMLEQLDMRRDVQEIFRLTPHEKQCMMFSATLSKDIRPVCRKFMQDPMEVFVDDETKLTLHGLQQYYVKLKDSEKNRKLFDLLDVLEFNQVIIFVKSVQRCMALAQLLVEQNFPAIAIHRGMAQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNIVFNYDMPEDSDTYLHRVARAGRFGTKGLAITFVSDENDAKILNDVQDRFEVNVAELPEEIDISTYIEQSR
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分子量
75.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DDX39, a member of the DEAD-box RNA helicase family, plays a crucial role in various cellular processes, including RNA metabolism, ribosome biogenesis, and gene expression regulation. As a critical component of the spliceosome, DDX39 is involved in pre-mRNA splicing, contributing to the removal of introns and the joining of exons, thereby influencing mRNA maturation and stability. Dysregulation of DDX39 has been linked to various cancers and genetic disorders, highlighting its potential as a therapeutic target. The study of recombinant DDX39 protein enables researchers to investigate its biochemical properties, structural characteristics, and functional mechanisms in detail. By producing this protein in a controlled environment, scientists can perform biochemical assays, structural analyses, and interaction studies, providing insights into its role in cellular processes and disease mechanisms. Furthermore, understanding the specific functions and regulation of DDX39 could pave the way for the development of novel therapeutic strategies aimed at modulating its activity in pathological conditions. Overall, the study of DDX39 recombinant protein is vital for elucidating its biological significance and exploring its potential in biomedical research and therapeutic applications.
