Analytical Data
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基因名
SOAT2
- Application
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别名
SOAT2; ACACT2; ACAT2; Sterol O-acyltransferase 2; EC 2.3.1.26; Acyl-coenzyme A:cholesterol acyltransferase 2; ACAT-2; Cholesterol acyltransferase 2
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O75908
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表达区间
1-522 aa
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氨基酸序列
MEPGGARLRLQRTEGLGGERERQPCGDGNTETHRAPDLVQWTRHMEAVKAQLLEQAQGQLRELLDRAMREAIQSYPSQDKPLPPPPPGSLSRTQEPSLGKQKVFIIRKSLLDELMEVQHFRTIYHMFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWARGTWTQATGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFLMKSYSFLREAVPGILRARRGEGIQAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKNFAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARGVAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMMHDQRTGPAWNVLMWTMLFLGQGIQVSLYCQEWYARRHCPLPQATFWGLVTPRSWSCHT
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分子量
86.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SOAT2 (Sterol O-acyltransferase 2) is an enzyme that plays a critical role in lipid metabolism, particularly in the esterification of free cholesterol and fatty acids into cholesteryl esters. This process is crucial for the regulation of lipid homeostasis and is implicated in various cellular functions, including membrane formation, signaling, and energy storage. Over the past decade, growing evidence has linked SOAT2 to several pathophysiological conditions, including atherosclerosis, obesity, and metabolic syndrome, triggering interest in its potential as a therapeutic target. Research has shown that SOAT2 is predominantly expressed in macrophages and other immune cells, where it influences inflammation and foam cell formation, both key components in atherogenesis and cardiovascular diseases. Recent studies have also explored the role of SOAT2 in neurodegenerative diseases, suggesting that its inhibition could be a promising strategy for neuroprotection. Consequently, the investigation of SOAT2 and the development of its recombinant proteins are of significant interest in the fields of biochemistry and pharmaceutical research, as they may provide novel insights into lipid metabolism and offer new avenues for therapeutic interventions in related diseases. Researchers are increasingly focused on elucidating the enzyme's structure and function, which may enhance our understanding of its role in health and disease, paving the way for innovative treatment strategies.
