Analytical Data
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Gene name
SOAT2
- Application
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Alternative Names
SOAT2; ACACT2; ACAT2; Sterol O-acyltransferase 2; EC 2.3.1.26; Acyl-coenzyme A:cholesterol acyltransferase 2; ACAT-2; Cholesterol acyltransferase 2
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O75908
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Expression Region
1-522 aa
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AA Sequence
MEPGGARLRLQRTEGLGGERERQPCGDGNTETHRAPDLVQWTRHMEAVKAQLLEQAQGQLRELLDRAMREAIQSYPSQDKPLPPPPPGSLSRTQEPSLGKQKVFIIRKSLLDELMEVQHFRTIYHMFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWARGTWTQATGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFLMKSYSFLREAVPGILRARRGEGIQAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKNFAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARGVAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMMHDQRTGPAWNVLMWTMLFLGQGIQVSLYCQEWYARRHCPLPQATFWGLVTPRSWSCHT
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Molecular Weight
86.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SOAT2 (Sterol O-acyltransferase 2) is an enzyme that plays a critical role in lipid metabolism, particularly in the esterification of free cholesterol and fatty acids into cholesteryl esters. This process is crucial for the regulation of lipid homeostasis and is implicated in various cellular functions, including membrane formation, signaling, and energy storage. Over the past decade, growing evidence has linked SOAT2 to several pathophysiological conditions, including atherosclerosis, obesity, and metabolic syndrome, triggering interest in its potential as a therapeutic target. Research has shown that SOAT2 is predominantly expressed in macrophages and other immune cells, where it influences inflammation and foam cell formation, both key components in atherogenesis and cardiovascular diseases. Recent studies have also explored the role of SOAT2 in neurodegenerative diseases, suggesting that its inhibition could be a promising strategy for neuroprotection. Consequently, the investigation of SOAT2 and the development of its recombinant proteins are of significant interest in the fields of biochemistry and pharmaceutical research, as they may provide novel insights into lipid metabolism and offer new avenues for therapeutic interventions in related diseases. Researchers are increasingly focused on elucidating the enzyme's structure and function, which may enhance our understanding of its role in health and disease, paving the way for innovative treatment strategies.
