Analytical Data
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基因名
DDI2
- Application
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别名
DDI1 DNA damage inducible 1 homolog 2; Ddi2; DDI2_HUMAN; DNA damage inducible 1 homolog 2 (S. cerevisiae); DNA damage inducible 1 homolog 2; DNA damage inducible protein 2; MGC14844; Protein DDI1 homolog 2; RP4-680D5.5
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q5TDH0
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表达区间
1-399aa
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氨基酸序列
MLLTVYCVRR DLSEVTFSLQ VDADFELHNF RALCELESGI PAAESQIVYA ERPLTDNHRS LASYGLKDGD VVILRQKENA DPRPPVQFPN LPRIDFSSIA VPGTSSPRQR QPPGTQQSHS SPGEITSSPQ GLDNPALLRD MLLANPHELS LLKERNPPLA EALLSGDLEK FSRVLVEQQQ DRARREQERI RLFSADPFDL EAQAKIEEDI RQQNIEENMT IAMEEAPESF GQVVMLYINC KVNGHPVKAF VDSGAQMTIM SQACAERCNI MRLVDRRWAG IAKGVGTQKI IGRVHLAQVQ IEGDFLPCSF SILEEQPMDM LLGLDMLKRH QCSIDLKKNV LVIGTTGSQT TFLPEGELPE CARLAYGAGR EDVRPEEIAD QELAEALQKS AEDAERQKP
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分子量
44.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DDI2 (DNA Damage-Inducible Protein 2) is a key regulator involved in cellular stress responses, particularly those related to DNA damage and protein quality control. Emerging research has highlighted its role in the ubiquitin-proteasome system, where it facilitates the degradation of misfolded proteins and plays a significant part in maintaining cellular homeostasis. Understanding the function of DDI2 is crucial, as dysregulation of its activity has been implicated in various diseases, including cancer and neurodegenerative disorders. The recombinant expression of DDI2 proteins provides a valuable tool for elucidating its biological functions and interactions. Through the study of its structural and functional properties, researchers aim to uncover the molecular mechanisms underlying DDI2’s involvement in cellular pathways. This understanding has potential therapeutic implications, particularly for developing strategies to modulate its activity in disease contexts, thereby opening new avenues for targeted drug discovery. The investigation of DDI2 recombinant proteins emphasizes the importance of post-translational modifications and the interplay between cellular stress responses and proteostasis, contributing to the broader field of molecular biology and the quest for elucidating protein function in health and disease.
