Analytical Data
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Gene name
SNX11
- Application
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Alternative Names
SNX11Sorting nexin-11
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y5W9
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Expression Region
1-270 aa
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AA Sequence
MGFWCRMSEN QEQEEVITVR VQDPRVQNEG SWNSYVDYKI FLHTNSKAFT AKTSCVRRRY REFVWLRKQL QRNAGLVPVP ELPGKSTFFG TSDEFIEKRR QGLQHFLEKV LQSVVLLSDS QLHLFLQSQL SVPEIEACVQ GRSTMTVSDA ILRYAMSNCG WAQEERQSSS HLAKGDQPKS CCFLPRSGRR SSPSPPPSEE KDHLEVWAPV VDSEVPSLES PTLPPLSSPL CCDFGRPKEG TSTLQSVRRA VGGDHAVPLD PGQLETVLEK
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Molecular Weight
30.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SNX11 (Sorting Nexin 11) is a member of the sorting nexin family, which plays a crucial role in various cellular processes, including endocytosis, trafficking, and signaling pathways. Recent research has highlighted its importance in neuronal function and synaptic plasticity, making SNX11 an attractive target for studying neurological disorders. The protein contains a phosphoinositide-binding domain that allows it to interact with specific lipids in cellular membranes, mediating the trafficking of proteins and receptors critical for neuronal signaling. Understanding the structure and function of SNX11, particularly through the study of its recombinant protein, can provide insights into its role in the pathogenesis of diseases such as Alzheimer's and schizophrenia. Moreover, engineers of recombinant SNX11 can facilitate the investigation of its interactions with other cellular components and its impact on intracellular signaling pathways, opening avenues for therapeutic interventions. The development of SNX11 as a recombinant protein is also significant for high-throughput screening assays and structural biology studies, enabling researchers to dissect its mechanism of action in detail. Overall, the exploration of SNX11 and its recombinant variants holds potential not just for elucidating fundamental biological processes but also for the identification of novel therapeutic strategies for neurodegenerative disorders.
