Analytical Data
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Gene name
SMYD5
- Application
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Alternative Names
Protein NN8 4AG; Protein NN8-4AG; Retinoic acid induced protein 15; Retinoic acid-induced protein 15; SET and MYND domain containing protein 5; SET and MYND domain-containing protein 5; SMYD5; SMYD5_HUMAN
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6GMV2
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Expression Region
1-418 aa
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AA Sequence
MSMCDVFS FCVGVAGRAR VSVEVRFVSS AKGKGLFATQ LIRKGETIFV ERPLVQFL WNALYRYRAC DHCLRALEKA EENAQRLTGK PGQVLPHPEL CTVRKDLHQN CPHCQVMYCS AECRLTEQ YHQVLCPGPS QDDPLHPLNK LQEAWRSIHY PPETASIMLM ARMVATVKQA KDKDRWIRLF SQFCNKTANE EEEIVHKLLG DKFKGQLELL RRLFTEALYE EAVSQWFTPD GFRSLFALVG TNGQGIGTSS LSQWVHACDT LELKPQDREQ LDAFIDQLYK DIETGEFL NCEGSGLFVL QSCCNHSCVP NAETSFPENN FLLHVTALED IKPGEEICIS YLDCCQRERS RHSRHKILRE NYLFVCSCPK CLAEADEPNV TSEEEEEEEE EEEGEPEDAE LGDEMTDV
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Molecular Weight
47.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SMYD5, a member of the SET and MYND domain-containing protein family, has garnered significant interest in recent years due to its emerging role in various biological processes and disease states, particularly in cancer. Structurally, SMYD5 is characterized by its SET domain, which is associated with histone methylation, suggesting that it may play a crucial role in gene regulation through epigenetic modification. Researchers have identified that SMYD5 is involved in the transcriptional regulation of oncogenes and tumor suppressor genes, influencing cell proliferation, differentiation, and survival. Mutations or dysregulation of SMYD5 have been implicated in several malignancies, highlighting its potential as a biomarker and therapeutic target. The production of recombinant SMYD5 protein allows for detailed studies of its biochemical properties, interactions with substrates, and its role in oncogenic pathways. By elucidating the mechanisms governing SMYD5 function, scientists aim to better understand its contributions to cancer biology and explore its potential as a target for novel therapeutic strategies. Thus, the development and characterization of SMYD5 recombinant protein invite further exploration into its functional roles and the possibility of developing SMYD5-targeted therapies in oncology.
