Analytical Data
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基因名
ARPC5L
- Application
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别名
ARPC5L；Actin-related Protein 2/3 complex subunit 5-like Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BPX5
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表达区间
1-154aa
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氨基酸序列
MSKNTVSSARFRKVDVDEYDENKFVDEEDGGDGQAGPDEGEVDSCLRHSITGNMTAALQAALKNPPINTKSQAVKDRAGSIVLKVLISFKANDIEKAVQSLDKNGVDLLMKYIYKGFESPSDNSSAMLLQWHEKALAAGGVGSIVRVLTARKTV
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分子量
16.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ARPC5L, a subunit of the Arp2/3 complex, plays a crucial role in the regulation of actin cytoskeleton dynamics, which is essential for various cellular processes, including cell motility, morphology, and division. Research has shown that ARPC5L is involved in diverse biological functions, such as immune responses, neuronal development, and tissue homeostasis. Its role in cancer progression and metastasis has garnered significant attention, as alterations in actin dynamics can lead to enhanced invasiveness of cancer cells. Given its importance in these physiological and pathological processes, the recombinant expression of ARPC5L provides an essential tool for exploring its structure-function relationship and investigating its potential as a therapeutic target. Researchers aim to produce high-quality recombinant ARPC5L proteins to study their interaction with other cellular components, elucidate the mechanisms underlying actin filament nucleation, and screen for potential inhibitors that could disrupt aberrant signaling pathways associated with cancer and other diseases. Understanding the functional significance of ARPC5L and its associated networks can potentially lead to novel strategies for treating diseases characterized by dysregulated actin dynamics.
