Analytical Data
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Gene name
SMTNL2
- Application
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Alternative Names
SMTNL2; Smoothelin-like protein 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q2TAL5
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Expression Region
1-461 aa
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AA Sequence
MEPAPDAQEA RTVREALGRY ELEGAVRA LHEDMRGLQR GVERRVAEAM RLAGPLARTV ADLQRDNQRL QAQLERLTRQ VEALGLASGM SPVPGTPGTP SPPPAPGVPD RAPRLGSARF ASHATFSLSG RGQSLDHDEA SESEMRKTSN SCIMENGHQP GAGPGDGPPE IAQNFSAPDP PRPRPVSLSL RLPHQPVTAI TRVSDRFSGE TSALSPMS TLGGLNPS PSEVITPWTP SPSEKNSSFT WSVPSSGYGA VTASKHSNSP PLVTPPQSPV SPQPPAITQV HRQGERRREL VRSQTLPRTS EAQARKALFE KWEQETGK GKGEARARLK RSQSFGVASA SSIKQILLEW CRSKTLGYQH VDLQNFSSSW SDGMAFCALV HSFFPDAFDY NSLSPTQRQK NFELAFTMAE NLANCERLIE VEDMMVMGRK PDPMCVFTYV QSLYNHLRRF E
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Molecular Weight
50.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SMTNL2, or Smoothelin-like protein 2, is a member of the smoothelin family, which is primarily expressed in smooth muscle tissues. Recent research has highlighted its role in various physiological and pathological processes, including muscle contraction, cell signaling, and tissue development. SMTNL2 has gained attention for its potential involvement in cardiovascular diseases and gastrointestinal disorders due to its expression in vascular smooth muscle and gastrointestinal smooth muscle. Studies have indicated that SMTNL2 is implicated in cellular mechanotransduction, where cells convert mechanical stimuli into biochemical signals, an essential process for maintaining tissue homeostasis. Furthermore, its role in regulating the cytoskeleton suggests that SMTNL2 may influence cell shape and motility. Given these functions, the recombinant production of SMTNL2 protein is crucial for elucidating its mechanisms of action and therapeutic potential. Researchers aim to employ recombinant SMTNL2 to study its biochemical properties, interaction with other proteins, and potential regulatory pathways. This foundational knowledge could pave the way for novel therapeutic strategies targeting SMTNL2 in diseases linked to smooth muscle dysfunction. Overall, understanding SMTNL2's biological importance and molecular interactions through recombinant technology can contribute significantly to the fields of cardiovascular research and gastrointestinal health.
