Analytical Data
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Gene name
FKBP10
- Application
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Alternative Names
FKBP10；FKBP65；Peptidyl-prolyl cis-trans isomerase FKBP10
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96AY3
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Expression Region
27-582aa
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AA Sequence
VGRG LGRASPAGGP LEDVVIERYH IPRACPREVQ MGDFVRYHYN GTFEDGKKFD SSYDRNTLVA IVVGVGRLIT GMDRGLMGMC VNERRRLIVP PHLGYGSIGL AGLIPPDATL YFDVVLLDVW NKEDTVQVST LLRPPHCPRM VQDGDFVRYH YNGTLLDGTS FDTSYSKGGT YDTYVGSGWL IKGMDQGLLG MCPGERRKII IPPFLAYGEK GYGTVIPPQA SLVFHVLLID VHNPKDAVQL ETLELPPGCV RRAGAGDFMR YHYNGSLMDG TLFDSSYSRN HTYNTYIGQG YIIPGMDQGL QGACMGERRR ITIPPHLAYG ENGTGDKIPG SAVLIFNVHV IDFHNPADVV EIRTLSRPSE TCNETTKLGD FVRYHYNCSL LDGTQLFTSH DYGAPQEATL GANKVIEGLD TGLQGMCVGE RRQLIVPPHL AHGESGARGV PGSAVLLFEV ELVSREDGLP TGYLFVWHKD PPANLFEDMD LNKDGEVPPE EFSTFIKAQV SEGKGRLMPG QDPEKTIGDM FQNQDRNQDG KITVDELKLK SDEDEERVHE EL
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FKBP10, a member of the FK506-binding protein family, plays a crucial role in protein folding and trafficking within the endoplasmic reticulum (ER). It is involved in several cellular processes, including the formation of protein complexes and the regulation of calcium homeostasis. Recent studies have highlighted its significance in various pathological conditions, including fibrosis, cancer, and neurodegenerative diseases. The investigation of FKBP10 recombinant protein has gained traction due to its potential as a therapeutic target and biomarker. By understanding the molecular mechanisms through which FKBP10 operates, researchers aim to explore its role in disease progression and develop strategies for intervention. Advances in protein expression systems have enabled the production of purified FKBP10 recombinant proteins, facilitating in-depth studies of its functional properties and interactions with other proteins. This research not only enhances our understanding of FKBP10's biological significance but also holds promise for the development of novel therapeutic approaches aimed at modulating its activity in disease contexts.
