Analytical Data
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基因名
SMCHD1
- Application
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别名
BAMS; FSHD2; KIAA0650; SMC hinge domain containing 1; SMC hinge domain containing protein 1; Smchd1; SMHD1_HUMAN; Structural maintenance of chromosomes flexible hinge domain containing 1; Structural maintenance of chromosomes flexible hinge domain-containing protein 1
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
A6NHR9
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表达区间
1-267 aa
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氨基酸序列
MVISWHLASDMDCVVTLTTDAARRIYDETQGRQQVLPLDSIYKKTLPDWKRSLPHFRNGKLYFKPIGDPVFARDLLTFPDNVEHCETVFGMLLGDTIILDNLDAANHYRKEVVKITHCPTLLTRDGDRIRSNGKFGGLQNKAPPMDKLRGMVFGAPVPKQCLILGEQIDLLQQYRSAVCKLDSVNKDLNSQLEYLRTPDMRKKKQELDEHEKNLKLIEEKLGMTPIRKCNDSLRHSPKVETTDCPVPPKRMRREATRQNRIITKTDV
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分子量
57.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Recombinant Human DAZAP2 Protein，GST
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Recombinant Human SMC2 Protein，GST
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Protein Description
SMCHD1 (Structural Maintenance of Chromosomes Flexible Hinge Domain Containing 1) is a crucial protein that plays a significant role in chromosome architecture and gene regulation. Research on SMCHD1 has gained momentum due to its association with various genetic disorders, including facioscapulohumeral muscular dystrophy (FSHD), a hereditary condition characterized by muscle weakness and wasting. This protein functions as a chromatin remodeler and is implicated in the maintenance of genomic stability, influencing the silencing of genes located in heterochromatin regions. Studies highlight its involvement in the three-dimensional organization of the nucleus and the regulation of transcriptional networks. The exploration of SMCHD1 recombinant proteins allows scientists to dissect its functional mechanisms at a molecular level, facilitating the identification of potential therapeutic targets for associated diseases. Furthermore, understanding the structural properties and interaction dynamics of SMCHD1 can shed light on its role within the broader context of epigenetic regulation and chromosomal dynamics. As such, SMCHD1 stands at the intersection of molecular biology, genetics, and potential clinical applications, driving research efforts to elucidate its significance in both normal cellular processes and pathological conditions.
