Analytical Data
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Gene name
FBXO32
- Application
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Alternative Names
FBXO32；F-box only Protein 32
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q969P5
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Expression Region
1-355aa
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AA Sequence
MPFLGQDWRS PGQNWVKTAD GWKRFLDEKS GSFVSDLSSY CNKEVYNKEN LFNSLNYDVA AKKRKKDMLN SKTKTQYFHQ EKWIYVHKGS TKERHGYCTL GEAFNRLDFS TAILDSRRFN YVVRLLELIA KSQLTSLSGI AQKNFMNILE KVVLKVLEDQ QNIRLIRELL QTLYTSLCTL VQRVGKSVLV GNINMWVYRM ETILHWQQQL NNIQITRPAF KGLTFTDLPL CLQLNIMQRL SDGRDLVSLG QAAPDLHVLS EDRLLWKKLC QYHFSERQIR KRLILSDKGQ LDWKKMYFKL VRCYPRKEQY GDTLQLCKHC HILSWKGTDH PCTANNPESC SVSLSPQDFI NLFKF
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
FBXO32, also known as Atrogin-1, is a member of the F-box protein family and plays a critical role in muscle protein degradation and cellular regulation. It was initially identified for its involvement in the ubiquitin-proteasome system, which targets proteins for degradation. Notably, FBXO32 has been implicated in muscle wasting conditions such as cachexia and sarcopenia, making it a focal point of research in muscle biology. Its expression is upregulated in response to various catabolic signals, including starvation and inflammation, leading to increased protein turnover. Understanding the mechanisms by which FBXO32 mediates protein degradation is crucial for developing therapeutic strategies to combat muscle atrophy. Recent studies have also suggested that FBXO32 may influence various cellular processes beyond muscle metabolism, including cell cycle regulation and response to stress, raising the importance of this protein in broader biological contexts. As researchers continue to explore FBXO32's function and regulation, the potential for therapeutic interventions targeting this pathway offers promising avenues for treating muscle-related diseases and enhancing muscle health in various populations.
