Analytical Data
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基因名
SLCO4C1
- Application
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别名
SLCO4C1; OATP4C1; OATPX; SLC21A20Solute carrier organic anion transporter family member 4C1; OATP-H; Organic anion transporter M1; OATP-M1; Solute carrier family 21 member 20
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6ZQN7
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表达区间
1-724 aa
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氨基酸序列
MKSAKGIENLAFVPSSPDILRRLSASPSQIEVSALSSDPQRENSQPQELQKPQEPQKSPEPSLPSAPPNVSEEKLRSLSLSEFEEGSYGWRNFHPQCLQRCNTPGGFLLHYCLLAVTQGIVVNGLVNISISTVEKRYEMKSSLTGLISSSYDISFCLLSLFVSFFGERGHKPRWLAFAAFMIGLGALVFSLPQFFSGEYKLGSLFEDTCVTTRNSTSCTSSTSSLSNYLYVFILGQLLLGAGGTPLYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYIDVAMGESTDVTEDDPRWLGAWWIGFLLSWIFAWSLIIPFSCFPKHLPGTAEIQAGKTSQAHQSNSNADVKFGKSIKDFPAALKNLMKNAVFMCLVLSTSSEALITTGFATFLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGFLVSKFRMTCKNTMKFALFTSGVALTLSFVFMYAKCENEPFAGVSESYNGTGELGNLIAPCNANCNCSRSYYYPVCGDGVQYFSPCFAGCSNPVAHRKPKVYYNCSCIERKTEITSTAETFGFEAKAGKCETHCAKLPIFLCIFFIVIIFTFMAGTPITVSILRCVNHRQRSLALGIQFMVLRLLGTIPGPIIFGFTIDSTCILWDINDCGIKGACWIYDNIKMAHMLVAISVTCKVITMFFNGFAIFLYKPPPSATDVSFHKENAVVTNVLAEQDLNKIVKEG
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分子量
106.59 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLCO4C1, a member of the solute carrier organic anion transporter family, is primarily involved in the transport of various endogenous compounds and xenobiotics across cellular membranes. Its expression is notably enriched in specific tissues such as the liver, brain, and placenta, suggesting its crucial role in physiological processes including drug disposition and hormonal transport. Recent research has highlighted SLCO4C1's potential involvement in pharmacogenomics, as variations in its gene may affect individual drug metabolism and response. Given its relevance in drug transport and potential implications for disease treatment, the study of SLCO4C1 has gained traction in both pharmacological and biomedical fields. The recombinant protein of SLCO4C1 serves as a valuable tool for investigating its transport mechanisms, substrate specificity, and interactions with various ligands. By characterizing the recombinant protein, researchers aim to elucidate its functional properties and the molecular determinants that govern substrate transport, thereby providing insights into its physiological role and therapeutic potential. Additionally, understanding SLCO4C1's functionality at the molecular level could lead to better predictions of drug behavior in patients, fostering the development of personalized medicine approaches. Overall, SLCO4C1 represents a significant target for research in drug transport and metabolism, with the potential to enhance our understanding of drug interactions and improve therapeutic outcomes.
