Analytical Data
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Gene name
CREBBP
- Application
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Alternative Names
CREBBP；CBP；CREB-binding Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q92793
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Expression Region
1319-1710aa
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AA Sequence
RK ENKFSAKRLQ TTRLGNHLED RVNKFLRRQN HPEAGEVFVR VVASSDKTVE VKPGMKSRFV DSGEMSESFP YRTKALFAFE EIDGVDVCFF GMHVQEYGSD CPPPNTRRVY ISYLDSIHFF RPRCLRTAVY HEILIGYLEY VKKLGYVTGH IWACPPSEGD DYIFHCHPPD QKIPKPKRLQ EWYKKMLDKA FAERIIHDYK DIFKQATEDR LTSAKELPYF EGDFWPNVLE ESIKELEQEE EERKKEESTA ASETTEGSQG DSKNAKKKNN KKTNKNKSSI SRANKKKPSM PNVSNDLSQK LYATMEKHKE VFFVIHLHAG PVINTLPPIV DPDPLLSCDL MDGRDAFLTL ARDKHWEFSS LRRSKWSTLC MLVELHTQGQ DRFVYTCNEC
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Molecular Weight
72 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CREBBP (CREB-binding protein) is a multifunctional coactivator that plays a crucial role in regulating gene expression by interacting with various transcription factors. Its significance has been underscored by its involvement in numerous biological processes, including cell proliferation, differentiation, and apoptosis. Mutations and aberrations in the CREBBP gene have been implicated in several human diseases, particularly cancers and developmental disorders such as Rubinstein-Taybi syndrome. The study of recombinant CREBBP protein is essential for understanding its functional mechanisms and pathways. Researchers often produce this protein using recombinant DNA technology to investigate its structure-function relationships, post-translational modifications, and interactions with other cellular proteins. By analyzing the recombinant CREBBP, scientists aim to elucidate its role in transcription regulation and its impact on disease mechanisms, paving the way for potential therapeutic strategies targeting CREBBP-related pathways. The development of CREBBP inhibitors or modulators could provide novel treatment options for conditions linked to its dysregulation, highlighting the importance of continued research in this area.
