Analytical Data
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Gene name
ROS1
- Application
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Alternative Names
ROS1；MCF3；ROS；Proto-oncogene tyrosine-Protein kinase ROS
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P08922
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Expression Region
1881-2347aa
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AA Sequence
VWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPT QEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVK TLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELME GRDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDL AARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAP ESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRL EPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSR DEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATE CGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPE GLNYACLTHSGYGDGSD
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Molecular Weight
82 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Research on recombinant ROS1 (Receptor of Activated C Kinase 1) proteins has gained prominence due to their critical roles in various biological processes and disease pathways, particularly in cancer. ROS1 is a receptor tyrosine kinase that, when rearranged or mutated, has been implicated in the pathogenesis of several tumors, notably non-small cell lung cancer (NSCLC). Understanding the structural and functional characteristics of ROS1 is crucial for the development of targeted therapies. With advancements in recombinant DNA technology, scientists can produce large quantities of pure ROS1 proteins, enabling detailed studies of their signaling mechanisms and interactions with other cellular proteins. This research facilitates the exploration of novel therapeutic strategies, including small-molecule inhibitors and monoclonal antibodies against aberrant ROS1 pathways. Additionally, studying recombinant ROS1 aids in the comprehension of its normal biological functions in cell proliferation and differentiation, thereby providing insights into potential clinical applications. The therapeutic potential of targeting ROS1 in oncology underscores the necessity for continued investigation into recombinant forms of the protein, as they hold promise for improving patient outcomes in ROS1-positive malignancies.
