Analytical Data
-
Gene name
SLC7A4
- Application
-
Alternative Names
CAT-4; CAT4; Cationic amino acid transporter 4; CTR4_HUMAN; HCAT3; Ig heavy chain variable region; MGC129976; MGC129977; SLC7A4; Solute carrier family 7 (cationic amino acid transporter; y+ system); member 4; Solute carrier family 7 member 4; VH 3 family; VH
-
Species
Human
-
Source
E. coli
-
Tag
GST-tag at N-terminal
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
O43246
-
Expression Region
1-635 aa
-
AA Sequence
MARGLPTIASLARLCQKLNRLKPLEDSIMETSLRRCLSTLDLTLLGVGGMVGSGLYVLTGAVAKEVAGPAVLLSFGVAAVASLLAALCYAEFGARVPRTGSAYLFTYVSMGELWAFLIGWNVLLEYIIGGAAVARAWSGYLDSMFSHSIRNFTETHVGSWQVPLLGHYPDFLAAGIILLASAFVSCGARVSSWLNHTFSAISLLVILFIVILGFILAQPHNWSADEGGFAPFGFSGVMAGTASCFYAFVGFDVIAASSEEAQNPRRSVPLAIAISLAIAAGAYILVSTVLTLMVPWHSLDPDSALADAFYQRGYRWAGFIVAAGSICAMNTVLLSLLFSLPRIVYAMATDGLFFQVFAHVHPRTQVPVAGTLAFGLLTAFLALLLDLESLVQFLSLGTLLAYTFVATSIIVLRFQKSSPPSSPGPASPGPLTKQQSSFSDHLQLVGTVHASVPEPGELKPALRPYLGFLDGYSPGAVVTWALGVMLASAITIGCVLVFGNSTLHLPHWGYILLLLLTSVMFLLSLLVLGAHQQQYREDLFQIPMVPLIPALSIVLNICLMLKLSYLTWVRFSIWLLMGLAVYFGYGIRHSKENQRELPGLNSTHYVVFPRGSLEETVQAMQPPSQAPAQDPGHME
-
Molecular Weight
96.25 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SLC7A4, also known as the solute carrier family 7 member 4, is a key transporter involved in the uptake of neutral amino acids, particularly in the kidney and other tissues. Its functional role is critical for maintaining amino acid homeostasis, nutrient absorption, and neurotransmitter regulation. Dysregulation of SLC7A4 has been implicated in various metabolic disorders and pathologies, including kidney diseases and neurological conditions. Consequently, the study of recombinant SLC7A4 protein is essential for elucidating its structure-function relationship, understanding its transport mechanisms, and identifying specific interactions with amino acids and other substrates. Research on SLC7A4 also extends to its potential as a therapeutic target, where modulating its activity could lead to innovative treatments for disorders linked to amino acid imbalances. Generating recombinant SLC7A4 allows for detailed biochemical assays, structural studies, and functional characterizations, contributing to the broader understanding of amino acid transport systems. By exploring the properties of SLC7A4, researchers aim to uncover its role in health and disease, paving the way for new clinical applications and insights into metabolic regulation.
