Analytical Data
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基因名
CUL9
- Application
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别名
CUL9；H7AP1；KIAA0708；PARC；Cullin-9
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8IWT3
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表达区间
全长
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氨基酸序列
full
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CUL9 (Cullin 9) is a member of the Cullin-RING E3 ubiquitin ligase family, which plays a critical role in ubiquitination, a process essential for protein degradation and cellular regulation. Emerging studies have highlighted CUL9's involvement in various biological processes, including cell cycle regulation, DNA damage response, and apoptosis. Its function is particularly intriguing due to its potential implications in cancer and neurodegenerative diseases, where dysregulation of ubiquitin-mediated pathways often occurs. Recent research has focused on the molecular mechanisms by which CUL9 interacts with substrate proteins and its regulatory pathways, revealing that it can modulate several key oncogenes and tumor suppressors. The reconstitution of CUL9 protein in experimental systems is pivotal for understanding its structural and functional properties, including substrate recognition and ligase activity. Utilizing recombinant CUL9 allows for detailed biochemical studies, characterizing its enzymatic activity and elucidating its role in cellular signaling networks. As researchers uncover the complexities of CUL9's interactions and regulatory roles, this could lead to novel therapeutic strategies targeting dysfunctional ubiquitin-proteasome pathways in various diseases.
