Analytical Data
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Gene name
SLC46A1
- Application
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Alternative Names
G21; HCP 1; HCP1; Heme carrier protein 1; MGC9564; PCFT; PCFT/HCP1; PCFT_HUMAN; PDE7A; Proton coupled folate transporter; Proton-coupled folate transporter; SLC46A1; Solute carrier family 46 (folate transporter) member 1; Solute carrier family 46 member 1
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96NT5
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AA Sequence
MEGSASPPEKPRARPAAAVLCRGPVEPLVFLANFALVLQGPLTTQYLWHRFSADLGYNGTRQRGGCSNRSADPTMQEVETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLASLGLLLQALVSVFVVQLQLHVGYFVLGRILCALLGDFGGLLAASFASVADVSSSRSRTFRMALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCFGETLKEPKSTRLFTFRHHRSIVQLYVAPAPEKSRKHLALYSLAIFVVITVHFGAQDILTLYELSTPLCWDSKLIGYGSAAQHLPYLTSLLALKLLQYCLADAWVAEIGLAFNILGMVVFAFATITPLMFTGALFSAVACVNSLAMLTASGIFNSLYPATLNFMKGFPFLLGAGLLLIPAVLIGMLEKADPHLEFQQFPQSP
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Molecular Weight
47.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLC46A1 (Solute Carrier Family 46 Member 1) is a key transporter protein involved in the absorption of various essential molecules, particularly folates and heme. Understanding its function and regulation is crucial for elucidating its role in pathological conditions, such as anemia and certain neurological disorders. Recent studies have highlighted the importance of SLC46A1 in intestinal absorption and transport across the blood-brain barrier, making it a potential target for therapeutic interventions. The recombinant expression of SLC46A1 allows for detailed investigations into its structure-function relationships, kinetic properties, and interaction with ligands, contributing to a deeper understanding of its biological significance. Moreover, characterizing the recombinant protein provides insights into the impact of genetic variations on transport activity, which can have implications in personalized medicine. As research into SLC46A1 progresses, the recombinant protein's role in nutrition and pharmacology, particularly in optimizing drug delivery and enhancing nutrient availability, continues to emerge as a significant area of interest. By utilizing various expression systems for producing recombinant SLC46A1, researchers aim to unravel the complexities of its mechanism of action, paving the way for novel strategies to address related health issues.
