Analytical Data
-
基因名
DYNC2LI1
- Application
-
别名
DYNC2LI1；D2LIC；LIC3；Cytoplasmic dynein 2 light intermediate chain 1
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q8TCX1
-
表达区间
1-352aa
-
氨基酸序列
MPSETLWEIAKAEVEKRGINGSEGDGAEIAEKFVFFIGSKNGGKTTIILRCLDRDEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSLVLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPQDHELIDPFPVPLVIIGSKYDVFQDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLAFGIDKSKSICVDQNKPLFITAGLDSFGQIGSPPVPENDIGKLHAHSPMELWKKVYEKLFPPKSINTLKDIKDPARDPQYAENEVDEMRIQKDLELEQYKRSSSKSWKQIELDS
-
分子量
44.8 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DYNC2LI1 is a critical component of the dynein motor protein complex, which plays a vital role in intracellular transport, particularly in the movement of organelles, vesicles, and other cargo along microtubules. Dysfunctional dynein activity has been implicated in various neurodegenerative diseases, such as Alzheimer’s and Huntington’s disease, as well as in congenital disorders affecting neuronal development. The study of DYNC2LI1, a light intermediate chain of cytoplasmic dynein-2, has gained attention due to its essential role in regulating dynein motor activity and cargo binding specificity. Researchers focus on reconstituting DYNC2LI1 protein to elucidate its structural properties and functional mechanisms, aiming to understand how mutations in this protein can lead to dysfunction in lysosomal trafficking and ciliary transport. Investigating DYNC2LI1 through recombinant protein techniques provides insights into its interactions with other protein partners within the dynein complex, thus contributing to a deeper understanding of the molecular pathways involved in cellular transport processes. Moreover, such studies could pave the way for therapeutic strategies targeting dynein-related pathologies. The growing interest in DYNC2LI1 reflects a broader commitment to unraveling the complexities of motor protein function in health and disease.
