Cat: PA1000-7697

Recombinant Human ABI1 Protein,His

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Analytical Data

  • Gene name

    ABI1

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    ABI1;SSH3BP1;Abl interactor 1

  • Species

    Human

  • Source

    E. coli

  • Tag

    His tag N-Terminus

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    Q8IZP0

  • Expression Region

    2-508aa

  • AA Sequence

    AELQMLLEE EIPSGKRALI ESYQNLTRVA DYCENNYIQA TDKRKALEET KAYTTQSLAS VAYQINALAN NVLQLLDIQA SQLRRMESSI NHISQTVDIH KEKVARREIG ILTTNKNTSR THKIIAPANM ERPVRYIRKP IDYTVLDDVG HGVKWLKAKH GNNQPARTGT LSRTNPPTQK PPSPPMSGRG TLGRNTPYKT LEPVKPPTVP NDYMTSPARL GSQHSPGRTA SLNQRPRTHS GSSGGSGSRE NSGSSSIGIP IAVPTPSPPT IGPENISVPP PSGAPPAPPL APLLPVSTVI AAPGSAPGSQ YGTMTRQISR HNSTTSSTSS GGYRRTPSVT AQFSAQPHVN GGPLYSQNSI SIAPPPPPMP QLTPQIPLTG FVARVQENIA DSPTPPPPPP PDDIPMFDDS PPPPPPPPVD YEDEEAAVVQ YNDPYADGDP AWAPKNYIEK VVAIYDYTKD KDDELSFMEG AIIYVIKKND DGWYEGVCNR VTGLFPGNYV ESIMHYTD

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

ABI1, or Abl interactor 1, is a critical regulator of various cellular processes, including cell proliferation, differentiation, and survival, primarily through its interactions with various signaling proteins. Research on ABI1 has garnered attention due to its role in the regulation of the Abelson (Abl) tyrosine kinase, which is implicated in several oncogenic pathways. The study of ABI1 recombinant protein is particularly important for understanding its function in cellular signaling and its potential contributions to cancer development. Recombinant ABI1 protein can be produced using various expression systems, enabling detailed biochemical analysis. This research aims to elucidate ABI1's structural and functional characteristics, explore its interaction with other signaling molecules, and investigate its potential as a therapeutic target. Understanding the mechanistic underpinnings of ABI1’s role in cellular signaling pathways may offer novel insights into cancer biology and identify new strategies for intervention in related diseases. Furthermore, characterization of the recombinant ABI1 protein can facilitate the development of tools for studying its biological effects in cell models, thus contributing to the broader field of cancer research and therapeutic development.

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