Analytical Data
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基因名
SLC35A1
- Application
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别名
CMP-SA-Tr; CMP-Sia-Tr; CMP-sialic acid transporter; S35A1_HUMAN; Slc35a1; Solute carrier family 35 member A1
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P78382
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表达区间
1-337 aa
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氨基酸序列
MAAPRDNVTLLFKLYCLAVMTLMAAVYTIALRYTRTSDKELYFSTTAVCITEVIKLLLSVGILAKETGSLGRFKASLRENVLGSPKELLKLSVPSLVYAVQNNMAFLALSNLDAAVYQVTYQLKIPCTALCTVLMLNRTLSKLQWVSVFMLCAGVTLVQWKPAQATKVVVEQNPLLGFGAIAIAVLCSGFAGVYFEKVLKSSDTSLWVRNIQMYLSGIIVTLAGVYLSDGAEIKEKGFFYGYTYYVWFVIFLASVGGLYTSVVVKYTDNIMKGFSAAAAIVLSTIASVMLFGLQITLTFALGTLLVCVSIYLYGLPRQDTTSIQQGETASKERVIGV
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分子量
63.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLC35A1, a member of the solute carrier family, encodes a nucleotide sugar transporter primarily involved in the transportation of UDP-glucuronic acid into the Golgi apparatus. This transporter plays a critical role in glycosylation processes, which are vital for the proper functioning of various proteins and lipids. Mutations in the SLC35A1 gene are linked to a rare autosomal recessive disorder known as Congenital Disorder of Glycosylation (CDG), specifically CDG-Iq. Patients with this disorder often exhibit a wide range of clinical symptoms, including developmental delays, neurological impairments, and immune dysfunction, highlighting the importance of SLC35A1 in maintaining cellular homeostasis and health. Research into recombinant SLC35A1 protein has focused on understanding its structure, function, and the mechanisms by which mutations lead to disease. Recombinant expression systems allow for the production of the protein in sufficient quantities for detailed biochemical studies, including substrate specificity and transport kinetics. These studies aim to elucidate the relationship between SLC35A1 dysfunction and disease, potentially paving the way for therapeutic interventions. Furthermore, understanding the transport mechanisms of SLC35A1 could provide insights into the broader implications of nucleotide sugar transport in glycosylation disorders, thereby advancing knowledge in both basic science and clinical approaches to treat related conditions.
