Analytical Data
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基因名
ZFAND6
- Application
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别名
ZFAND6；AWP1；ZA20D3；AN1-type zinc finger Protein 6
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6FIF0
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表达区间
1-208aa
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氨基酸序列
MAQETNHSQV PMLCSTGCGF YGNPRTNGMC SVCYKEHLQR QNSSNGRISP PATSVSSLSE SLPVQCTDGS VPEAQSALDS TSSSMQPSPV SNQSLLSESV ASSQLDSTSV DKAVPETEDV QASVSDTAQQ PSEEQSKSLE KPKQKKNRCF MCRKKVGLTG FECRCGNVYC GVHRYSDVHN CSYNYKADAA EKIRKENPVV VGEKIQKI
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ZFAND6 is a member of the ZFAND (Zinc Finger ANaphase Promoting Complex) protein family, which plays a significant role in various cellular processes, including the regulation of the cell cycle and response to stress. The research into ZFAND6 has gained traction due to its involvement in modulating the activity of the anaphase-promoting complex/cyclosome (APC/C), a crucial regulator of mitotic progression and cell cycle transition. Studies suggest that ZFAND6 may interact with key ubiquitin-protein ligases, contributing to protein degradation pathways that are essential for maintaining cellular homeostasis. Aberrant expression or function of ZFAND6 has been linked to various diseases, including cancer, whereby its altered regulation may lead to unchecked cell proliferation. Investigating the structural and functional aspects of ZFAND6, including its interactions with other cellular factors and its role in ubiquitination processes, is critical for understanding its potential as a therapeutic target. Furthermore, elucidating the molecular mechanisms governing ZFAND6's activity may provide insights into broader cellular regulatory networks, offering a foundation for future studies aimed at developing interventions in diseases associated with its dysfunction.
