Analytical Data
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Gene name
SLC25A46
- Application
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Alternative Names
SLC25A46; TB1; Solute carrier family 25 member 46
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96AG3
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Expression Region
1-418 aa
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AA Sequence
MHPRRPDGFDGLGYRGGARDEQGFGGAFPARSFSTGSDLGHWVTTPPDIPGSRNLHWGEKSPPYGVPTTSTPYEGPTEEPFSSGGGGSVQGQSSEQLNRFAGFGIGLASLFTENVLAHPCIVLRRQCQVNYHAQHYHLTPFTVINIMYSFNKTQGPRALWKGMGSTFIVQGVTLGAEGIISEFTPLPREVLHKWSPKQIGEHLLLKSLTYVVAMPFYSASLIETVQSEIIRDNTGILECVKEGIGRVIGMGVPHSKRLLPLLSLIFPTVLHGVLHYIISSVIQKFVLLILKRKTYNSHLAESTSPVQSMLDAYFPELIANFAASLCSDVILYPLETVLHRLHIQGTRTIIDNTDLGYEVLPINTQYEGMRDCINTIRQEEGVFGFYKGFGAVIIQYTLHAAVLQITKIIYSTLLQNNI
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Molecular Weight
72.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLC25A46 is a gene encoding a mitochondrial carrier protein that has garnered attention due to its role in mitochondrial function and the pathogenesis of neurodegenerative diseases. Mutations in SLC25A46 are linked to conditions such as early-onset progressive ataxia and neuropathy, suggesting its critical involvement in maintaining mitochondrial integrity and function. Research has shown that SLC25A46 plays a pivotal role in the regulation of mitochondrial dynamics, particularly in the processes of mitochondrial fusion and fission. Understanding the structure and function of the SLC25A46 recombinant protein is essential to elucidate its mechanisms in mitochondrial biology and disease. Recent studies employing recombinant protein techniques have aimed to characterize SLC25A46, exploring its transport capabilities and interactions with other mitochondrial proteins. This knowledge is vital for developing potential therapeutic strategies targeting mitochondrial dysfunctions associated with SLC25A46 mutations. The investigation of SLC25A46 as a biochemical entity not only enhances our understanding of basic mitochondrial biology but also sheds light on its clinical significance, paving the way for new approaches in treating mitochondrial-related diseases.
