Analytical Data
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Gene name
PSMC4
- Application
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Alternative Names
PSMC4；MIP224；TBP7；26S proteasome regulatory subunit 6B
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P43686
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Expression Region
1-418aa
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AA Sequence
MEEIGILVEK AQDEIPALSV SRPQTGLSFL GPEPEDLEDL YSRYKKLQQE LEFLEVQEEY IKDEQKNLKK EFLHAQEEVK RIQSIPLVIG QFLEAVDQNT AIVGSTTGSN YYVRILSTID RELLKPNASV ALHKHSNALV DVLPPEADSS IMMLTSDQKP DVMYADIGGM DIQKQEVREA VELPLTHFEL YKQIGIDPPR GVLMYGPPGC GKTMLAKAVA HHTTAAFIRV VGSEFVQKYL GEGPRMVRDV FRLAKENAPA IIFIDEIDAI ATKRFDAQTG ADREVQRILL ELLNQMDGFD QNVNVKVIMA TNRADTLDPA LLRPGRLDRK IEFPLPDRRQ KRLIFSTITS KMNLSEEVDL EDYVARPDKI SGADINSICQ ESGMLAVREN RYIVLAKDFE KAYKTVIKKD EQEHEFYK
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PSMC4, a subunit of the 26S proteasome complex, plays a crucial role in cellular protein degradation and regulation, which is essential for maintaining cellular homeostasis. The proteasome is responsible for the targeted degradation of ubiquitin-tagged proteins, facilitating various cellular processes, including the cell cycle, signal transduction, and responses to stress. Research into PSMC4 has gained importance due to its involvement in diverse pathophysiological conditions, including cancer, neurodegenerative diseases, and viral infections. Alterations in proteasome activity and composition, particularly involving PSMC4, can lead to the accumulation of misfolded proteins, contributing to cellular dysfunction and disease progression. Furthermore, PSMC4 has been identified as a potential biomarker and therapeutic target, making its study relevant for developing novel treatments. Recent advances in proteomics and molecular biology have enabled scientists to explore PSMC4's structure, function, and interactions within the proteasome and its impact on various signaling pathways. Understanding PSMC4's role in the proteasome's dynamic assembly and function could provide deeper insights into its contribution to cellular health and disease mechanisms, paving the way for innovative therapeutic strategies aimed at diseases associated with proteasome dysfunction. Consequently, ongoing research continues to elucidate PSMC4's multifaceted roles, thereby enhancing our comprehension of proteasomal regulation and its implications for human health.
