Analytical Data
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Gene name
CSEN
- Application
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Alternative Names
A type potassium channel modulatory protein 3; A-type potassium channel modulatory protein 3; AI413860; Calsenilin; CSEN; CSEN_HUMAN; DRE antagonist modulator; DRE-antagonist modulator
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y2W7
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Expression Region
1-256aa
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AA Sequence
MQPAKEVTKASDGSLLGDLGHTPLSKKEGIKWQRPRLSRQALMRCCLVKWILSSTAPQGSDSSDSELELSTVRHQPEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYAQFFPQGDATTYAHFLFNAFDADGNGAIHFEDFVVGLSILLRGTVHEKLKWAFNLYDINKDGYITKEEMLAIMKSIYDMMGRHTYPILREDAPAEHVERFFEKMDRNQDGVVTIEEFLEACQKDENIMSSMQLFENVI
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Molecular Weight
53.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CSEN, or C-terminal Src kinase (Csk)-binding protein, is a critical component in cellular signaling pathways, particularly in the regulation of Src family kinases, which play a pivotal role in various cellular processes such as growth, proliferation, and differentiation. Due to its involvement in modulating immune responses and cancer progression, understanding the structural and functional characteristics of CSEN is paramount. Recent studies have shown that CSEN can interact with multiple signaling proteins, highlighting its potential as a novel target for therapeutic interventions. The reconstitution of CSEN as a recombinant protein facilitates detailed investigations into its biochemical properties, interaction networks, and cellular functions. This research aims to elucidate the specific mechanisms by which CSEN influences Src kinase activity and its downstream effects on signaling pathways. Additionally, the recombinant form of CSEN can serve as a valuable tool for high-throughput screening of potential inhibitors, paving the way for the development of targeted therapies in cancer and autoimmune diseases. As a result, the study of CSEN not only enhances our understanding of fundamental cellular processes but also holds promise for innovative therapeutic strategies.
