Analytical Data
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Gene name
BMX
- Application
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Alternative Names
BMX；Cytoplasmic tyrosine-Protein kinase BMX
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P51813
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Expression Region
1-675aa
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AA Sequence
MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGS RKGSIEIKKIRCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRS QWLKALQKEIRGNPHLLVKYHSGFFVDGKFLCCQQSCKAAPGCTLWEAYA NLHTAVNEEKHRVPTFPDRVLKIPRAVPVLKMDAPSSSTTLAQYDNESKK NYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDFPDWWQVRKLK SSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGN ISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYH VHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVP DSVSLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEG SMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNY LRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCV KVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGI LMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWH ELPEKRPTFQQLLSSIEPLREKDKH
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Molecular Weight
110 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
BMX (B lymphoid tyrosine kinase) is a member of the Tec family of non-receptor tyrosine kinases, which plays a crucial role in various cellular processes, including cell signaling, proliferation, and survival. Originally identified in B lymphocytes, BMX has since been implicated in the signaling pathways of other cell types, particularly during immune responses and oncogenesis. Its activity is regulated by various post-translational modifications and interactions with signaling molecules, making it a critical component in the transmission of extracellular signals to intracellular responses. Recent studies have shown that BMX is overexpressed in several types of cancers, suggesting that it may contribute to tumorigenesis by promoting cell survival and proliferation through the activation of downstream signaling pathways such as the PI3K/Akt and NF-κB pathways. This has led to increased interest in BMX as a potential therapeutic target for cancer treatment. Additionally, understanding the structural and functional dynamics of BMX, including its various isoforms, is essential for developing inhibitors that can effectively disrupt its activity. With advancements in molecular biology techniques, researchers are now better equipped to investigate the detailed mechanisms of BMX regulation and its role in disease contexts, paving the way for novel approaches in targeted therapies. As the field progresses, elucidating the complete functional repertoire of BMX and its interactions will be vital for translating these findings into clinical applications.
