Analytical Data
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基因名
BMX
- Application
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别名
BMX；Cytoplasmic tyrosine-Protein kinase BMX
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P51813
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表达区间
1-675aa
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氨基酸序列
MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGS RKGSIEIKKIRCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRS QWLKALQKEIRGNPHLLVKYHSGFFVDGKFLCCQQSCKAAPGCTLWEAYA NLHTAVNEEKHRVPTFPDRVLKIPRAVPVLKMDAPSSSTTLAQYDNESKK NYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDFPDWWQVRKLK SSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGN ISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYH VHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVP DSVSLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEG SMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNY LRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCV KVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGI LMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWH ELPEKRPTFQQLLSSIEPLREKDKH
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分子量
110 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BMX (B lymphoid tyrosine kinase) is a member of the Tec family of non-receptor tyrosine kinases, which plays a crucial role in various cellular processes, including cell signaling, proliferation, and survival. Originally identified in B lymphocytes, BMX has since been implicated in the signaling pathways of other cell types, particularly during immune responses and oncogenesis. Its activity is regulated by various post-translational modifications and interactions with signaling molecules, making it a critical component in the transmission of extracellular signals to intracellular responses. Recent studies have shown that BMX is overexpressed in several types of cancers, suggesting that it may contribute to tumorigenesis by promoting cell survival and proliferation through the activation of downstream signaling pathways such as the PI3K/Akt and NF-κB pathways. This has led to increased interest in BMX as a potential therapeutic target for cancer treatment. Additionally, understanding the structural and functional dynamics of BMX, including its various isoforms, is essential for developing inhibitors that can effectively disrupt its activity. With advancements in molecular biology techniques, researchers are now better equipped to investigate the detailed mechanisms of BMX regulation and its role in disease contexts, paving the way for novel approaches in targeted therapies. As the field progresses, elucidating the complete functional repertoire of BMX and its interactions will be vital for translating these findings into clinical applications.
