Analytical Data
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基因名
CRNKL1
- Application
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别名
C80326; CLF; Clf1; CRN; Crn crooked neck like 1 (Drosophila); Crnkl1; CRNL1_HUMAN; Crooked neck homolog; Crooked neck like protein 1; Crooked neck pre mRNA splicing factor 1; Crooked neck-like protein 1; hCrn; MGC55327; MGC93283; MSTP021; SYF3; SYF3 pre mRNA splicing factor
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BZJ0
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表达区间
1-848aa
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氨基酸序列
MTATVENLTFQKDTLGNAVDKNTSRLELRSYSLAGRHGSTEPLVLAWSSQFRRLTWGCALDALHRSPCVAASQHGVTHLIRSSRTPHSTRCRKEDAQPGHHGNGAASVTAQARGQRSVLQVPLPVPRSCLFSESFVVSVSSQSRFLASVPGTGVQRSTAADMAASTAAGKQRIPKVAKVKNKAPAEVQITAEQLLREAKERELELLPPPPQQKITDEEELNDYKLRKRKTFEDNIRKNRTVISNWIKYAQWEESLKEIQRARSIYERALDVDYRNITLWLKYAEMEMKNRQVNHARNIWDRAITTLPRVNQFWYKYTYMEEMLGNVAGARQVFERWMEWQPEEQAWHSYINFELRYKEVDRARTIYERFVLVHPDVKNWIKYARFEEKHAYFAHARKVYERAVEFFGDEHMDEHLYVAFAKFEENQKEFERVRVIYKYALDRISKQDAQELFKNYTIFEKKFGDRRGIEDIIVSKRRFQYEEEVKANPHNYDAWFDYLRLVESDAEAEAVREVYERAIANVPPIQEKRHWKRYIYLWINYALYEELEAKDPERTRQVYQASLELIPHKKFTFAKMWILYAQFEIRQKNLSLARRALGTSIGKCPKNKLFKVYIELELQLREFDRCRKLYEKFLEFGPENCTSWIKFAELETILGDIDRARAIYELAISQPRLDMPEVLWKSYIDFEIEQEETERTRNLYRRLLQRTQHVKVWISFAQFELSSGKEGSLTKCRQIYEEANKTMRNCEEKEERLMLLESWRSFEEEFGTASDKERVDKLMPEKVKKRRKVQTDDGSDAGWEEYFDYIFPEDAANQPNLKLLAMAKLWKKQQQEKEDAEHHPDEDVDESES
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分子量
119.68 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CRNKL1, or Cytokine Receptor-NK Cell Ligand 1, is a newly identified protein implicated in immune regulation, particularly concerning natural killer (NK) cells. Research has shown that CRNKL1 plays a crucial role in modulating the immune response by influencing NK cell activation and function. The significance of CRNKL1 has emerged with increasing interest in targeted immunotherapies for cancer and viral infections, where enhancing NK cell activity is paramount. Studies indicate that CRNKL1 interacts with various cytokine receptors, potentially serving as a co-stimulatory or inhibitory factor, thus shaping the overall immune landscape. The recombinant expression of CRNKL1 protein enables thorough investigations into its functional properties, interactions, and potential therapeutic applications. Understanding the mechanisms through which CRNKL1 affects NK cell dynamics may pave the way for novel immunotherapeutic strategies aimed at boosting anti-tumor immunity or modulating immune responses in chronic infections. As more data becomes available, CRNKL1 may emerge as a critical player in both basic immunology and clinical applications, warranting further exploration and characterization of its biochemical properties and functional roles within the immune system.
