Analytical Data
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Gene name
CRNKL1
- Application
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Alternative Names
C80326; CLF; Clf1; CRN; Crn crooked neck like 1 (Drosophila); Crnkl1; CRNL1_HUMAN; Crooked neck homolog; Crooked neck like protein 1; Crooked neck pre mRNA splicing factor 1; Crooked neck-like protein 1; hCrn; MGC55327; MGC93283; MSTP021; SYF3; SYF3 pre mRNA splicing factor
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BZJ0
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Expression Region
1-848aa
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AA Sequence
MTATVENLTFQKDTLGNAVDKNTSRLELRSYSLAGRHGSTEPLVLAWSSQFRRLTWGCALDALHRSPCVAASQHGVTHLIRSSRTPHSTRCRKEDAQPGHHGNGAASVTAQARGQRSVLQVPLPVPRSCLFSESFVVSVSSQSRFLASVPGTGVQRSTAADMAASTAAGKQRIPKVAKVKNKAPAEVQITAEQLLREAKERELELLPPPPQQKITDEEELNDYKLRKRKTFEDNIRKNRTVISNWIKYAQWEESLKEIQRARSIYERALDVDYRNITLWLKYAEMEMKNRQVNHARNIWDRAITTLPRVNQFWYKYTYMEEMLGNVAGARQVFERWMEWQPEEQAWHSYINFELRYKEVDRARTIYERFVLVHPDVKNWIKYARFEEKHAYFAHARKVYERAVEFFGDEHMDEHLYVAFAKFEENQKEFERVRVIYKYALDRISKQDAQELFKNYTIFEKKFGDRRGIEDIIVSKRRFQYEEEVKANPHNYDAWFDYLRLVESDAEAEAVREVYERAIANVPPIQEKRHWKRYIYLWINYALYEELEAKDPERTRQVYQASLELIPHKKFTFAKMWILYAQFEIRQKNLSLARRALGTSIGKCPKNKLFKVYIELELQLREFDRCRKLYEKFLEFGPENCTSWIKFAELETILGDIDRARAIYELAISQPRLDMPEVLWKSYIDFEIEQEETERTRNLYRRLLQRTQHVKVWISFAQFELSSGKEGSLTKCRQIYEEANKTMRNCEEKEERLMLLESWRSFEEEFGTASDKERVDKLMPEKVKKRRKVQTDDGSDAGWEEYFDYIFPEDAANQPNLKLLAMAKLWKKQQQEKEDAEHHPDEDVDESES
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Molecular Weight
119.68 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CRNKL1, or Cytokine Receptor-NK Cell Ligand 1, is a newly identified protein implicated in immune regulation, particularly concerning natural killer (NK) cells. Research has shown that CRNKL1 plays a crucial role in modulating the immune response by influencing NK cell activation and function. The significance of CRNKL1 has emerged with increasing interest in targeted immunotherapies for cancer and viral infections, where enhancing NK cell activity is paramount. Studies indicate that CRNKL1 interacts with various cytokine receptors, potentially serving as a co-stimulatory or inhibitory factor, thus shaping the overall immune landscape. The recombinant expression of CRNKL1 protein enables thorough investigations into its functional properties, interactions, and potential therapeutic applications. Understanding the mechanisms through which CRNKL1 affects NK cell dynamics may pave the way for novel immunotherapeutic strategies aimed at boosting anti-tumor immunity or modulating immune responses in chronic infections. As more data becomes available, CRNKL1 may emerge as a critical player in both basic immunology and clinical applications, warranting further exploration and characterization of its biochemical properties and functional roles within the immune system.
