Cat: PA2000-6871

Recombinant Human CRKRS Protein,GST

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Analytical Data

  • 基因名

    CRKRS

  • Application

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    arginine/serine-rich; Cdc2 related kinase arginine/serine rich; CDC2 related protein kinase 7; Cdc2-related kinase; CDC2-related protein kinase 7; Cdk12; CDK12_HUMAN; Cell division cycle 2 related protein kinase 7; Cell division cycle 2-related protein kinase 7

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    GST-tag at N-terminal

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    Q9NYV4

  • 表达区间

    1281-1380aa

  • 氨基酸序列

    LVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL

  • 分子量

    36.63 kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

CRKRS, or Cysteine-Rich Protein Kinase Regulated by Stress, has garnered significant attention in recent years due to its critical role in cellular response to stress and its potential implications in various diseases, including cancer and neurodegenerative disorders. As a member of the protein kinase family, CRKRS is involved in various signaling pathways that regulate cellular activities such as proliferation, differentiation, and apoptosis. Research has shown that CRKRS expression levels can be influenced by various stressors, including oxidative stress, hypoxia, and nutrient deprivation, leading to its involvement in cellular adaptation mechanisms. Understanding the structure and functional mechanisms of CRKRS is vital for unraveling its role in stress response pathways and identifying potential therapeutic targets for diseases where these pathways are dysregulated. Recent advances in recombinant protein technology have enabled the production of CRKRS in a laboratory setting, facilitating detailed studies on its biochemical properties and interactions with other cellular components. By generating and characterizing CRKRS recombinant proteins, researchers aim to elucidate the protein's structure-function relationships and its regulatory mechanisms, paving the way for novel strategies in disease intervention and treatment. This research not only enhances our fundamental understanding of cellular responses to stress but also holds the promise of translating basic science into innovative therapeutic approaches for improving human health.

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Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
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