Analytical Data
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Gene name
SLC22A7
- Application
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Alternative Names
hOAT2; liver specific transporter; NLT; Novel liver transporter; OAT2; Organic anion transporter 2; Organic anion transporter member 7; Organic anion transporter member 7 Fragment; S22A7_HUMAN; SLC22A7; solute carrier family 22 (organic anion transporter) member 7; Solute carrier family 22; Solute carrier family 22 member 7
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y694
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Expression Region
1-548 aa
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AA Sequence
MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSHQDVWLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTSLQEEEMPMKQVQN
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Molecular Weight
86.02 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SLC22A7, a member of the SLC22 family of solute carrier transporters, has garnered significant interest in recent years due to its role in the transport of various organic cations, including drugs and metabolites. It is primarily expressed in the kidney and liver, where it plays a crucial role in the renal excretion and hepatic uptake of substances. Dysregulation of SLC22A7 has been implicated in various diseases, including hypertension and diabetes, highlighting its potential as a therapeutic target. The recombinant protein of SLC22A7 is essential for elucidating its biochemical properties and functions, allowing researchers to investigate its substrate specificity and transport mechanisms. Furthermore, studying the recombinant protein aids in the identification of pharmacological inhibitors and facilitators, which can enhance drug design and therapeutic applications. As research progresses, understanding the structure-function relationship of SLC22A7 through recombinant protein studies could pave the way for novel insights into drug transport dynamics and disease management, ultimately contributing to the development of more effective therapeutic strategies.
