Analytical Data
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基因名
clfB
- Application
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别名
clfB；KPP；Keratin. type I cytoskeletal 10
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种属
E.coli
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O86476
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表达区间
45-542aa
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氨基酸序列
SEQSNDTTQSSKNNASADSEKNNMIETPQLNTTANDTSDISANTNSANVDSTTKPMSTQTSNTTTTEPASTNETPQPTAIKNQATAAKMQDQTVPQEANSQVDNKTTNDANSIATNSELKNSQTLDLPQSSPQTISNAQGTSKPSVRTRAVRSLAVAEPVVNAADAKGTNVNDKVTASNFKLEKTTFDPNQSGNTFMAANFTVTDKVKSGDYFTAKLPDSLTGNGDVDYSNSNNTMPIADIKSTNGDVVAKATYDILTKTYTFVFTDYVNNKENINGQFSLPLFTDRAKAPKSGTYDANINIADEMFNNKITYNYSSPIAGIDKPNGANISSQIIGVDTASGQNTYKQTVFVNPKQRVLGNTWVYIKGYQDKIEESSGKVSATDTKLRIFEVNDTSKLSDSYYADPNDSNLKEVTDQFKNRIYYEHPNVASIKFGDITKTYVVLVEGHYDNTGKNLKTQVIQENVDPVTNRDYSIFGWNNENVVRYGGGSADGDSAVN
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分子量
56.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ClfB, or Clumping Factor B, is a protein found in Staphylococcus aureus, a pathogenic bacterium responsible for a wide range of infections in humans, from minor skin infections to severe diseases such as pneumonia and sepsis. Research into ClfB has grown significantly due to its role in the adhesion of S. aureus to host tissues, facilitating colonization and infection. ClfB functions by binding to fibrinogen, a key component of blood that is involved in the clotting process, thus promoting bacterial attachment to host cells. Understanding ClfB's structure and function is crucial for the development of potential therapeutic strategies, including vaccines and novel anti-infective agents. Recombinant ClfB protein production allows researchers to study its biological properties in detail, offering insights into its mechanisms of action and its interactions with the host immune system. Additionally, recombinant ClfB can be utilized in serological assays to help diagnose S. aureus infections or as a target for vaccine development. Overall, the study of ClfB is essential for elucidating the virulence mechanisms of S. aureus and for contributing to the advancement of effective treatments against infections caused by this formidable pathogen.
