Analytical Data
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基因名
SKB1
- Application
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别名
72 kDa ICln binding protein; 72 kDa ICln-binding protein; ANM5_HUMAN; Histone synthetic lethal 7; S. cerevisiae; homolog of; Histone-arginine N-methyltransferase PRMT5; HMT1 hnRNP methyltransferase like 5; HOMOLOG OF; SKB1; HRMT1L5; IBP72; Jak-binding protein 1; JBP 1; JBP1; PRMT 5; PRMT5; Protein arginine methyltransferase 5; Protein arginine N methyltransferase 5; Protein arginine N methyltransferase 5 N terminally processed; Protein arginine N-methyltransferase 5; S. POMBE; S. POMBE HOMOLOG OF; SKB1; SHK1 KINASE BINDING PROTEIN 1; Shk1 kinase binding protein 1 homolog; Shk1 kinase-binding protein 1 homolog; Shk1 kinase/binding protein 1; S. pombe; homolog of; SKB 1; SKB1; SKB1 homolog; SKB1: SKB1 homolog (S. pombe); SKB1Hs
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O14744
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表达区间
1-637 aa
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氨基酸序列
MAAMAVGGAG GSRVSSGRDL NCVPEIADTL GAVAKQGFDF LCMPVFHPRF KREFIQEPAK NRPGPQTRSD LLLSGRDWNT LIVGKLSPWI RPDSKVEKIR RNSEAAMLQE LNFGAYLGLP AFLLPLNQED NTNLARVLTN HIHTGHHSSM FWMRVPLVAP EDLRDDIIEN APTTHTEEYS GEEKTWMWWH NFRTLCDYSK RIAVALEIGA DLPSNHVIDR WLGEPIKAAI LPTSIFLTNK KGFPVLSKMH QRLIFRLLKL EVQFIITGTN HHSEKEFCSY LQYLEYLSQN RPPPNAYELF AKGYEDYLQS PLQPLMDNLE SQTYEVFEKD PIKYSQYQQA IYKCLLDRVP EEEKDTNVQV LMVLGAGRGP LVNASLRAAK QADRRIKLYA VEKNPNAVVT LENWQFEEWG SQVTVVSSDM REWVAPEKAD IIVSELLGSF ADNELSPECL DGAQHFLKDD GVSIPGEYTS FLAPISSSKL YNEVRACREK DRDPEAQFEM PYVVRLHNFH QLSAPQPCFT FSHPNRDPMI DNNRYCTLEF PVEVNTVLHG FAGYFETVLY QDITLSIRPE THSPGMFSWF PILFPIKQPI TVREGQTICV RFWRCSNSKK VWYEWAVTAP VCSAIHNPTG RSYTIGL
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分子量
72.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SKB1 (Shu-associated Kinase Binding 1) is a protein implicated in various cellular processes, including stress response, DNA damage repair, and cell cycle regulation. Research into SKB1 has gained momentum due to its potential role in cancer biology and cellular signaling pathways. As a member of the stress-activated protein kinases, SKB1 is believed to influence cell survival and apoptosis under adverse conditions, making it a promising target for therapeutic interventions. The study of SKB1 is further motivated by its association with key proteins involved in tumor progression and metastasis, suggesting that understanding its function and regulatory mechanisms could offer insights into cancer development and treatment. Recent advancements in recombinant protein technology have enabled the production of SKB1 in a pure and functional form, facilitating structural and functional analyses. Researchers are now exploring the biochemical properties of SKB1, including its interactions with other proteins and its role in signal transduction pathways. Furthermore, the potential of SKB1 as a biomarker for cancer prognosis and treatment response is under investigation, highlighting its relevance in the clinical setting. Continued research on SKB1 is essential to unravel its complex regulation and provide a foundation for developing novel therapeutic strategies targeting this protein in various diseases.
