Analytical Data
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基因名
CAMK2A
- Application
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别名
CAMK2A；CAMKA；KIAA0968；Calcium/calmodulin-dependent Protein kinase type II subunit alpha
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UQM7
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表达区间
1-478aa
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氨基酸序列
MATITCTRFT EEYQLFEELG KGAFSVVRRC VKVLAGQEYA AKIINTKKLS ARDHQKLERE ARICRLLKHP NIVRLHDSIS EEGHHYLIFD LVTGGELFED IVAREYYSEA DASHCIQQIL EAVLHCHQMG VVHRDLKPEN LLLASKLKGA AVKLADFGLA IEVEGEQQAW FGFAGTPGYL SPEVLRKDPY GKPVDLWACG VILYILLVGY PPFWDEDQHR LYQQIKAGAY DFPSPEWDTV TPEAKDLINK MLTINPSKRI TAAEALKHPW ISHRSTVASC MHRQETVDCL KKFNARRKLK GAILTTMLAT RNFSGGKSGG NKKSDGVKES SESTNTTIED EDTKVRKQEI IKVTEQLIEA ISNGDFESYT KMCDPGMTAF EPEALGNLVE GLDFHRFYFE NLWSRNSKPV HTTILNPHIH LMGDESACIA YIRITQYLDA GGIPRTAQSE ETRVWHRRDG KWQIVHFHRS GAPSVLPH
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CAMK2A (calcium/calmodulin-dependent protein kinase II alpha) is a pivotal serine/threonine kinase that plays a critical role in various cellular processes, particularly in synaptic plasticity, learning, and memory. Research on CAMK2A has gained significant attention due to its involvement in neurodegenerative diseases and psychiatric disorders, where dysregulation of calcium signaling and kinase activity can lead to impaired synaptic function. The recombinant protein of CAMK2A allows researchers to study its structure, enzymatic activity, and interactions with various substrates and regulatory proteins in a controlled environment. By producing and purifying CAMK2A, scientists can perform biochemical assays to elucidate its functional mechanisms and role in signal transduction pathways. Additionally, understanding the conformational changes and activation mechanisms of CAMK2A through recombinant studies provides insights into its dual roles as a kinase and a molecular scaffold. This knowledge can pave the way for potential therapeutic strategies targeting CAMK2A in treating neurological disorders. Furthermore, recombinant CAMK2A can be used in the development of biosensors or in vivo models to further investigate its physiological functions and implications in brain health. Overall, the exploration of CAMK2A recombinant protein is crucial for dissecting the intricate signaling networks underlying neuronal function and for advancing our understanding of brain diseases.
