Analytical Data
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基因名
CNNM3
- Application
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别名
CNNM3; ACDP3; Metal transporter CNNM3; Ancient conserved domain-containing protein 3; Cyclin-M3
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8NE01
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表达区间
1-355aa
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氨基酸序列
MLDASTVLDFGVLASIMQSGHTRIPVYEEERSNIVDMLYLKDLAFVDPEDCTPLSTITRFYNHPLHFVFNDTKLDAVLEEFKRGDTVVKRKPASLMAPLKRKEEFSLFKVSDDEYKVTISPQLLLATQRFLSREVDVFSPLRISEKVLLHLLKHPSVNQEVRFDESNRLATHHYLYQRSQPVDYFILILQGRVEVEIGKEGLKFENGAFTYYGVSALTVPSSVHQSPVSSLQPIRHDLQPDPGDGTHSSAYCPDYTVRALSDLQLIKVTRLQYLNALLATRAQNLPQSPENTDLQVIPGSQTRLLGEKTTTAAGSSHSRPSLPLLPRGRDSAAYSDSDLFGLSHLVSAVTAFVWP
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分子量
64.68 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of CNNM3 recombinant proteins has garnered attention due to their potential roles in various physiological and pathological processes. CNNM3, a member of the cyclin M family, is primarily involved in magnesium transport and homeostasis, which is critical for numerous cellular functions. Abnormalities in CNNM3 expression and function have been linked to several diseases, including cancer and neurodegenerative disorders. As magnesium is essential for over 300 enzymatic reactions in the human body, understanding the mechanisms governing its transport can provide insights into novel therapeutic targets. Researchers have focused on characterizing CNNM3's structure and function through recombinant protein expression techniques, facilitating the investigation of its interactions with other cellular components. This research may help elucidate the molecular pathways influenced by CNNM3 and its potential as a biomarker or therapeutic target in diseases associated with magnesium dysregulation. Furthermore, recombinant CNNM3 proteins serve as valuable tools in pharmacological studies and the development of new strategies to modulate magnesium transport, thereby highlighting their significance in both basic and applied biomedical research.
