Analytical Data
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Gene name
CNNM3
- Application
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Alternative Names
CNNM3; ACDP3; Metal transporter CNNM3; Ancient conserved domain-containing protein 3; Cyclin-M3
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8NE01
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Expression Region
1-355aa
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AA Sequence
MLDASTVLDFGVLASIMQSGHTRIPVYEEERSNIVDMLYLKDLAFVDPEDCTPLSTITRFYNHPLHFVFNDTKLDAVLEEFKRGDTVVKRKPASLMAPLKRKEEFSLFKVSDDEYKVTISPQLLLATQRFLSREVDVFSPLRISEKVLLHLLKHPSVNQEVRFDESNRLATHHYLYQRSQPVDYFILILQGRVEVEIGKEGLKFENGAFTYYGVSALTVPSSVHQSPVSSLQPIRHDLQPDPGDGTHSSAYCPDYTVRALSDLQLIKVTRLQYLNALLATRAQNLPQSPENTDLQVIPGSQTRLLGEKTTTAAGSSHSRPSLPLLPRGRDSAAYSDSDLFGLSHLVSAVTAFVWP
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Molecular Weight
64.68 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The study of CNNM3 recombinant proteins has garnered attention due to their potential roles in various physiological and pathological processes. CNNM3, a member of the cyclin M family, is primarily involved in magnesium transport and homeostasis, which is critical for numerous cellular functions. Abnormalities in CNNM3 expression and function have been linked to several diseases, including cancer and neurodegenerative disorders. As magnesium is essential for over 300 enzymatic reactions in the human body, understanding the mechanisms governing its transport can provide insights into novel therapeutic targets. Researchers have focused on characterizing CNNM3's structure and function through recombinant protein expression techniques, facilitating the investigation of its interactions with other cellular components. This research may help elucidate the molecular pathways influenced by CNNM3 and its potential as a biomarker or therapeutic target in diseases associated with magnesium dysregulation. Furthermore, recombinant CNNM3 proteins serve as valuable tools in pharmacological studies and the development of new strategies to modulate magnesium transport, thereby highlighting their significance in both basic and applied biomedical research.
