Analytical Data
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Gene name
CNKSR1
- Application
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Alternative Names
Connector enhancer of KSR 1;CNK homolog protein 1;CNK1;hCNK1;Connector enhancer of KSR-like
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q969H4
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Expression Region
1-720aa
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AA Sequence
MEPVETWTPGKVATWLRGLDDSLQDYPFEDWQLPGKNLLQLCPQSLEALAVRSLGHQELILGGVEQLQALSSRLQTENLQSLTEGLLGATHDFQSIVQGCLGDCAKTPIDVLCAAVELLHEADALLFWLSRYLFSHLNDFSACQEIRDLLEELSQVLHEDGPAAEKEGTVLRICSHVAGICHNILVCCPKELLEQKAVLEQVQLDSPLGLEIHTTSNCQHFVSQVDTQVPTDSRLQIQPGDEVVQINEQVVVREERDMVGWPRKNMVRELLREPAGLSLVLKKIPIPETPPQTPPQVLDSPHQRSPSLSLAPLSPRAPSEDVFAFDLSSNPSPGPSPAWTDSASLGPEPLPIPPEPPAILPAGVAGTPGLPESPDKSPVGRKKSKGLATRLSRRRVSCRELGRPDCDGWLLLRKAPGGFMGPRWRRRWFVLKGHTLYWYRQPQDEKAEGLINVSNYSLESGHDQKKKYVFQLTHDVYKPFIFAADTLTDLSMWVRHLITCISKYQSPGRAPPPREEDCYSETEAEDPDDEAGSHSASPSPAQAGSPLHGDTSPAATPTQRSPRTSFGSLTDSSEEALEGMVRGLRQGGVSLLGQPQPLTQEQWRSSFMRRNRDPQLNERVHRVRALQSTLKAKLQELQVLEEVLGDPELTGEKFRQWKEQNRELYSEGLGAWGVAQAEGSSHILTSDSTEQSPHSLPSDPEEHSHLCPLTSESSLRPPDL
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Molecular Weight
81.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CNKSR1 (Connector Enhancer of KSR1) is a multi-domain scaffold protein involved in various signaling pathways, particularly in the regulation of MAPK (Mitogen-Activated Protein Kinase) signaling. This protein plays a crucial role in cellular processes such as growth, differentiation, and apoptosis. Research on CNKSR1 has gained traction due to its implications in various cancers and developmental disorders. Studies have shown that CNKSR1 interacts with key signaling molecules, including KSR1 and several Rho-family GTPases, facilitating the assembly of protein complexes that modulate signal transduction. Moreover, mutations or alterations in CNKSR1 expression have been linked to tumorigenesis, making it a potential biomarker or therapeutic target. Understanding the structure and function of CNKSR1 is critical for elucidating its role in signaling pathways and developing innovative strategies for cancer treatment. Consequently, recombinant CNKSR1 protein has become an important tool in research, aiding in the investigation of its functional mechanisms and potential interactions within cellular signaling networks. As researchers continue to explore the complexities of CNKSR1, the potential for novel therapeutic applications in cancer and other diseases remains a promising area of study.
