Analytical Data
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Gene name
SESTD1
- Application
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Alternative Names
huntingtin interacting protein like protein; Huntingtin-interacting protein-like protein; Protein Solo; SEC14 and spectrin domains 1; SEC14 domain and spectrin repeat-containing protein 1; SESD1_HUMAN; sestd1; SOLO
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q86VW0
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Expression Region
1-696 aa
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AA Sequence
MEASVILPIL KKKLAFLSGG KDRRSGLILT IPLCLEQTNM DELSVTLDYL LSIPSEKCKA RGFTVIVDGR KSQWNVVKTV VVMLQNVVPA EVSLVCVVKP DEFWDKKVTH FCFWKEKDRL GFEVILVSAN KLTRYIEPCQ LTEDFGGSLT YDHMDWLNKR LVFEKFTKES TSLLDELALI NNGSDKGNQQ EKERSVDLNF LPSVDPETVL QTGHELLSEL QQRRFNGSDG GVSWSPMDDE LLAQPQVMKL LDSLREQYTR YQEVCRQRSK RTQLEEIQQK VMQVVNWLEG PGSEQLRAQW GIGDSIRASQ ALQQKHEEIE SQHSEWFAVY VELNQQIAAL LNAGDEEDLV ELKSLQQQLS DVCYRQASQL EFRQNLLQAA LEFHGVAQDL SQQLDGLLGM LCVDVAPADG ASIQQTLKLL EEKLKSVDVG LQGLREKGQG LLDQISNQAS WAYGKDVTIE NKENVDHIQG VMEDMQLRKQ RCEDMVDVRR LKMLQMVQLF KCEEDAAQAV EWLSELLDAL LKTHIRLGDD AQETKVLLEK HRKFVDVAQS TYDYGRQLLQ ATVVLCQSLR CTSRSSGDTL PRLNRVWKQF TIASEERVHR LEMAIAFHSN AEKILQDCPE EPEAINDEEQ FDEIEAVGKS LLDRLTVPVV YPDGTEQYFG SPSDMASTAE NIRDRMKLVN LKRQQLRHPE MVTTES
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Molecular Weight
79.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SESTD1 (Suppressor of EGFR signaling pathway 1) is a novel protein that has garnered attention in the field of molecular biology and cancer research due to its role in modulating the signaling pathways associated with the Epidermal Growth Factor Receptor (EGFR). Elevated EGFR signaling is implicated in various cancers, making it a critical target for therapeutic intervention. SESTD1's function as an adaptor protein suggests it may play a crucial role in the recruitment and organization of signaling complexes that influence cell proliferation and survival. Recent studies indicate that SESTD1 may also interact with other key proteins involved in cellular stress responses and apoptosis, further underscoring its potential significance in oncogenesis and tumor progression. Understanding the molecular mechanisms through which SESTD1 operates could provide valuable insights for the development of targeted therapies, particularly in cancers characterized by dysregulated EGFR signaling. Consequently, the research on SESTD1 recombinant protein is essential for elucidating its biological functions, determining its potential as a biomarker, and investigating its therapeutic applications in cancer treatment. The generation and characterization of SESTD1 recombinant protein not only facilitate functional studies but also pave the way for the exploration of its role in cellular signaling networks, contributing to a more comprehensive understanding of cancer biology and the design of innovative therapeutic strategies.
