Analytical Data
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Gene name
CD22
- Application
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Alternative Names
CD22；SIGLEC2；B-cell receptor CD22
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P20273
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Expression Region
22-685aa
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AA Sequence
SKWVFEHPETLYAWEGACVWIPCTYRALDGDLESFILFHNPEYNKNTSKF DGTRLYESTKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRM ESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYP IQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQL QDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSN PEYTTVSWLKDGTSLKKQNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSE EVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGK EMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKK VTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVLK IQNVGWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHS GNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLNFDSISPEDAGSYSC WVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDAN PPVSHYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSP LSTLTVYYSPETIG
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Molecular Weight
75 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CD22 is a transmembrane glycoprotein critically involved in the regulation of B-cell receptor (BCR) signaling, thereby playing a vital role in B-cell development, activation, and survival. As a member of the immunoglobulin superfamily, CD22 serves as a crucial negative regulator of B-cell activation, helping maintain immune homeostasis. Its dysregulation is associated with various B-cell malignancies and autoimmune diseases, making it an important target for therapeutic interventions. The study of CD22 recombinant proteins has gained traction due to their potential in understanding B-cell signaling pathways and developing novel immunotherapies. Furthermore, recombinant CD22 proteins can be utilized to generate specific antibodies or chimeric antigen receptor (CAR) T cells for targeted treatment of CD22-positive tumors, such as certain leukemias and lymphomas. Investigating the structural and functional aspects of CD22 through recombinant technologies not only enhances our comprehension of B-cell biology but also paves the way for innovative strategies in cancer immunotherapy and autoimmune disorder management. With the growing interest in engineered proteins and their therapeutic implications, research on CD22 recombinant proteins holds promise for advancing personalized medicine and improving patient outcomes in hematological malignancies.
