Analytical Data
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基因名
SERAC1
- Application
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别名
SERAC1; Protein SERAC1; Serine active site-containing protein 1
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96JX3
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表达区间
1-654 aa
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氨基酸序列
MSLAAYCVICCRRIGTSTSPPKSGTHWRDIRNIIKFTGSLILGGSLFLTYEVLALKKAVTLDTQVVEREKMKSYIYVHTVSLDKGENHGIAWQARKELHKAVRKVLATSAKILRNPFADPFSTVDIEDHECAVWLLLRKSKSDDKTTRLEAVREMSETHHWHDYQYRIIAQACDPKTLIGLARSEESDLRFFLLPPPLPSLKEDSSTEEELRQLLASLPQTELDECIQYFTSLALSESSQSLAAQKGGLWCFGGNGLPYAESFGEVPSATVEMFCLEAIVKHSEISTHCDKIEANGGLQLLQRLYRLHKDCPKVQRNIMRVIGNMALNEHLHSSIVRSGWVSIMAEAMKSPHIMESSHAARILANLDRETVQEKYQDGVYVLHPQYRTSQPIKADVLFIHGLMGAAFKTWRQQDSEQAVIEKPMEDEDRYTTCWPKTWLAKDCPALRIISVEYDTSLSDWRARCPMERKSIAFRSNELLRKLRAAGVGDRPVVWISHSMGGLLVKKMLLEASTKPEMSTVINNTRGIIFYSVPHHGSRLAEYTVNIRYLLFPSLEVKELSKDSPALKTLQDDFLEFAKDKNFQVLNFVETLPTYIGSMIKLHVVPVESADLGIGDLIPVDVNHLNICKPKKKDAFLYQRTLQFIREALAKDLEN
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分子量
100.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SERAC1, a protein associated with the biogenesis of mitochondrial membranes, plays a crucial role in lipid metabolism and mitochondrial function. Mutations in the SERAC1 gene are linked to a rare, inherited disorder known as SERAC1 deficiency, characterized by neurological deficits and impaired cellular respiration. Understanding the structure and function of SERAC1 is essential for uncovering its mechanisms in mitochondrial dynamics and lipid homeostasis. Recent studies have focused on the recombinant expression of SERAC1, allowing for the detailed investigation of its biochemical properties and interaction with other mitochondrial proteins. This research not only enhances our knowledge of SERAC1's role in cellular metabolism but also paves the way for potential therapeutic strategies to address disorders associated with SERAC1 dysfunction. Furthermore, the use of recombinant proteins facilitates the development of assays to screen for small molecules that could modulate SERAC1 activity, offering new avenues for drug discovery in the treatment of mitochondrial diseases. As the interest in mitochondrial research continues to grow, the study of SERAC1 stands out as a significant area that bridges the gap between basic science and clinical applications, aiming to provide insights into the underlying causes of mitochondrial pathologies.
