Cat: PA1000-7194

Recombinant Human TPP1 Protein,His

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Analytical Data

  • Gene name

    TPP1

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    TPP1;CLN2;Tripeptidyl-peptidase 1

  • Species

    Human

  • Source

    E. coli

  • Tag

    His tag N-Terminus

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    O14773

  • Expression Region

    196-563aa

  • AA Sequence

    LHLGV TPSVIRKRYN LTSQDVGSGT SNNSQACAQF LEQYFHDSDL AQFMRLFGGN FAHQASVARV VGQQGRGRAG IEASLDVQYL MSAGANISTW VYSSPGRHEG QEPFLQWLML LSNESALPHV HTVSYGDDED SLSSAYIQRV NTELMKAAAR GLTLLFASGD SGAGCWSVSG RHQFRPTFPA SSPYVTTVGG TSFQEPFLIT NEIVDYISGG GFSNVFPRPS YQEEAVTKFL SSSPHLPPSS YFNASGRAYP DVAALSDGYW VVSNRVPIPW VSGTSASTPV FGGILSLINE HRILSGRPPL GFLNPRLYQQ HGAGLFDVTR GCHESCLDEE VEGQGFCSGP GWDPVTGWGT PNFPALLKTL LNP

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

Quality inspection process

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Protein Description

TPP1 (Telomere-Associated Protein 1) is a critical protein involved in various cellular processes, including telomere maintenance, DNA repair, and regulation of gene expression. Research on TPP1 has gained significant attention due to its essential role in the protection of chromosome ends, thereby preventing telomere shortening and cellular senescence. Mutations or dysregulation of TPP1 are associated with several genetic disorders and contribute to the aging process and cancer development. Moreover, TPP1 interacts with other proteins, such as the telomerase complex and shelterin components, highlighting its importance in maintaining genomic integrity. Recent advances in recombinant protein technology have enabled scientists to produce TPP1 in vitro, providing opportunities to explore its structure-function relationship and biochemical properties. This research is crucial for understanding the mechanisms underlying telomere biology and its implications for therapeutic strategies targeting age-related diseases and cancer. Overall, the study of recombinant TPP1 not only sheds light on its biological significance but also paves the way for potential clinical applications.

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