Analytical Data
-
基因名
TPP1
- Application
-
别名
TPP1；CLN2；Tripeptidyl-peptidase 1
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
O14773
-
表达区间
196-563aa
-
氨基酸序列
LHLGV TPSVIRKRYN LTSQDVGSGT SNNSQACAQF LEQYFHDSDL AQFMRLFGGN FAHQASVARV VGQQGRGRAG IEASLDVQYL MSAGANISTW VYSSPGRHEG QEPFLQWLML LSNESALPHV HTVSYGDDED SLSSAYIQRV NTELMKAAAR GLTLLFASGD SGAGCWSVSG RHQFRPTFPA SSPYVTTVGG TSFQEPFLIT NEIVDYISGG GFSNVFPRPS YQEEAVTKFL SSSPHLPPSS YFNASGRAYP DVAALSDGYW VVSNRVPIPW VSGTSASTPV FGGILSLINE HRILSGRPPL GFLNPRLYQQ HGAGLFDVTR GCHESCLDEE VEGQGFCSGP GWDPVTGWGT PNFPALLKTL LNP
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TPP1 (Telomere-Associated Protein 1) is a critical protein involved in various cellular processes, including telomere maintenance, DNA repair, and regulation of gene expression. Research on TPP1 has gained significant attention due to its essential role in the protection of chromosome ends, thereby preventing telomere shortening and cellular senescence. Mutations or dysregulation of TPP1 are associated with several genetic disorders and contribute to the aging process and cancer development. Moreover, TPP1 interacts with other proteins, such as the telomerase complex and shelterin components, highlighting its importance in maintaining genomic integrity. Recent advances in recombinant protein technology have enabled scientists to produce TPP1 in vitro, providing opportunities to explore its structure-function relationship and biochemical properties. This research is crucial for understanding the mechanisms underlying telomere biology and its implications for therapeutic strategies targeting age-related diseases and cancer. Overall, the study of recombinant TPP1 not only sheds light on its biological significance but also paves the way for potential clinical applications.
