Analytical Data
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基因名
SEMA6D
- Application
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别名
SEMA6D; KIAA1479; Semaphorin-6D
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8NFY4
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表达区间
1-476 aa
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氨基酸序列
MRVFLLCAYILLLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQLMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAK
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分子量
80.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SEMA6D, a member of the semaphorin family, plays a crucial role in regulating neuronal guidance, angiogenesis, and immune responses. This protein is particularly interesting due to its complex interactions with various receptors, including plexins and neuropilins, which mediate signaling pathways essential for development and tissue homeostasis. Research has indicated that SEMA6D may be implicated in several pathological conditions, such as cancer progression, neurodevelopmental disorders, and autoimmune diseases. Understanding its molecular mechanisms and the pathways it influences is vital for elucidating its role in these diseases. Recent studies have shown that SEMA6D may impact tumor microenvironments and immune cell interactions, making it a potential biomarker and therapeutic target. As researchers strive to uncover the full spectrum of SEMA6D's functions, the focus is also on its structure-function relationships that govern its biological activities. This pursuit not only enhances our knowledge of SEMA6D itself but also contributes to broader insights into the roles of semaphorins in various physiological and pathological processes, ultimately paving the way for innovative therapeutic strategies.
