Analytical Data
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Gene name
SIGIRR
- Application
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Alternative Names
SIGIRR；Single Ig IL-1-related receptor
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Species
Mouse
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9JLZ8-1
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Expression Region
1-238aa
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AA Sequence
MAGVCDMAPN FLSPSEDQAL GLALGREVAL NCTAWVFSRP QCPQPSVQWL KDGLALGNGS HFSLHEDFWV SANFSEIVSS VLVLNLTNAE DYGTFTCSVW NVSSHSFTLW RAGPAGHVAA VLASLLVLVV LLLVALLYVK CRLNMLLWYQ DTYGEVEMND GKLYDAYVSY SDCPEDRKFV NFILKPQLER RRGYKLFLED RDLLPRAEPS ADLLVNLSRC RRLIVVLSDA FLSRPWCS
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Molecular Weight
41 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SIGIRR, or Single Immunoglobulin Interleukin-1 Receptor-related molecule, is a member of the Toll-like receptor (TLR) signaling pathway and plays a crucial role in modulating immune responses. Research into SIGIRR has gained significance due to its potential implications in both innate and adaptive immunity, particularly in the context of inflammatory diseases and autoimmune disorders. SIGIRR functions as a negative regulator, preventing excessive inflammation by inhibiting pro-inflammatory cytokine production and promoting homeostasis within the immune system. Its expression is primarily found in immune cells, including dendritic cells and macrophages, where it acts to fine-tune host responses to pathogens. Dysregulation of SIGIRR has been linked to various diseases, such as rheumatoid arthritis, Crohn’s disease, and sepsis, highlighting its therapeutic potential. Recent studies have investigated the structural characteristics of SIGIRR, revealing its unique immunoglobulin-like domains that facilitate interactions with other signaling molecules. Understanding these mechanisms at a molecular level is essential for developing targeted therapies, as enhancing SIGIRR function could provide a novel approach to treating hyper-inflammatory conditions. Overall, the exploration of SIGIRR's role in immune regulation is pivotal for advancing our knowledge of immune-mediated diseases and could lead to the development of innovative strategies in immunotherapy and disease management. As the scientific community continues to unravel the complexities of SIGIRR, its potential as a biomarker and target for therapeutic intervention in inflammatory and autoimmune diseases remains a promising area of research.
