Analytical Data
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基因名
SEC14L1
- Application
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别名
SEC14L1; SEC14L; SEC14-like protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q92503
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表达区间
1-715 aa
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氨基酸序列
MVQKYQSPVR VYKYPFELIM AAYERRFPTC PLIPMFVGSD TVNEFKSEDG AIHVIERRCK LDVDAPRLLK KIAGVDYVYF VQKNSLNSRE RTLHIEAYNE TFSNRVIINE HCCYTVHPEN EDWTCFEQSA SLDIKSFFGF ESTVEKIAMK QYTSNIKKGK EIIEYYLRQL EEEGITFVPR WSPPSITTSS ETSSSSSKKQ AASMAVVIPE AALKEGLSGD ALSSPSAPEP VVGTPDDKLD ADYIKRYLGD LTPLQESCLI RLRQWLQETH KGKIPKDEHI LRFLRARDFN IDKAREIMCQ SLTWRKQHQV DYILETWTPP QVLQDYYAGG WHHHDKDGRP LYVLRLGQMD TKGLVRALGE EALLRYVLSI NEEGLRRCEE NTKVFGRPIS SWTCLVDLEG LNMRHLWRPG VKALLRIIEV VEANYPETLG RLLILRAPRV FPVLWTLVSP FIDDNTRRKF LIYAGNDYQG PGGLLDYIDK EIIPDFLSGE CMCEVPEGGL VPKSLYRTAE ELENEDLKLW TETIYQSASV FKGAPHEILI QIVDASSVIT WDFDVCKGDI VFNIYHSKRS PQPPKKDSLG AHSITSPGGN NVQLIDKVWQ LGRDYSMVES PLICKEGESV QGSHVTRWPG FYILQWKFHS MPACAASSLP RVDDVLASLQ VSSHKCKVMY YTEVIGSEDF RGSMTSLESS HSGFSQLSAA TTSSSQSHSS SMISR
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分子量
81.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SEC14L1, a member of the SEC14 protein family, plays a crucial role in intracellular lipid transport and metabolism. This protein is primarily associated with the regulation of phosphatidylinositol and phosphatidylcholine levels, both of which are vital for various cellular processes, including membrane trafficking and cellular signaling. Mutations in SEC14L1 have been linked to a range of diseases, particularly those affecting neurological function, highlighting its importance in brain development and function. Research has shown that SEC14L1 is involved in the regulation of lipid droplet biogenesis and cellular energy metabolism, making it a significant focus for understanding metabolic disorders. Additionally, its broad expression pattern across different tissues suggests a fundamental role in maintaining cellular homeostasis. Ongoing studies aim to elucidate the precise mechanisms of SEC14L1's functions and its interactions with other cellular components, with the hope that this knowledge will lead to novel therapeutic strategies for conditions rooted in lipid metabolism dysregulation. Given the increasing prevalence of metabolic disorders worldwide, understanding SEC14L1 and its pathways could pave the way for innovative approaches to treatment and prevention.
