Analytical Data
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Gene name
GNA13
- Application
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Alternative Names
GNA13；Guanine nucleotide-binding Protein subunit alpha-13
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14344
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Expression Region
1-377aa
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AA Sequence
MADFLPSRSVLSVCFPGCLLTSGEAEQQRKSKEIDKCLSREKTYVKRLVK ILLLGAGESGKSTFLKQMRIIHGQDFDQRAREEFRPTIYSNVIKGMRVLV DAREKLHIPWGDNSNQQHGDKMMSFDTRAPMAAQGMVETRVFLQYLPAIR ALWADSGIQNAYDRRREFQLGESVKYFLDNLDKLGEPDYIPSQQDILLAR RPTKGIHEYDFEIKNVPFKMVDVGGQRSERKRWFECFDSVTSILFLVSSS EFDQVLMEDRLTNRLTESLNIFETIVNNRVFSNVSIILFLNKTDLLEEKV QIVSIKDYFLEFEGDPHCLRDVQKFLVECFRNKRRDQQQKPLYHHFTTAI NTENIRLVFRDVKDTILHDNLKQLMLQ
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Molecular Weight
67 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GNA13, a member of the Rho GTPase family, plays a crucial role in various cellular processes, including cytoskeletal dynamics, cell migration, and proliferation. Its function is vital in many physiological and pathological conditions, such as cardiovascular diseases and cancer. The study of GNA13 has garnered attention due to its involvement in signaling pathways that regulate cell shape and movement, especially its role in the activation of downstream effectors that modulate actin cytoskeleton organization. Research has revealed that aberrant regulation of GNA13 activity can lead to altered cellular behaviors, contributing to tumorigenesis and metastasis. This has prompted efforts to develop GNA13 as a potential therapeutic target. To further investigate its complex biological functions and interactions, researchers have utilized recombinant protein technology to produce GNA13 in sufficient quantities for detailed structural and functional studies. The reconstitution of GNA13 into cellular systems allows for the elucidation of its mechanisms of action and interactions with other proteins, ultimately enhancing our understanding of its role in health and disease. As our knowledge of GNA13 expands, it may provide new avenues for intervention in diseases where its pathways are dysregulated, underscoring the importance of continued research in this area.
